IHC (Immunohistochemisry)
(SNCA/Alpha-Synuclein Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit SNCA/Alpha-Synuclein Polyclonal Antibody | anti-SNCA antibody
SNCA/Alpha-Synuclein Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Gene Names
SNCA; PD1; NACP; PARK1; PARK4
Reactivity
Chicken, Sheep, Mouse, Dog, Rat, Pig, Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
SNCA/Alpha-Synuclein, Antibody; SNCA/Alpha-Synuclein Rabbit anti-Human Polyclonal (N-Terminus) Antibody; PathPlus SNCA/Alpha-Synuclein Antibody (N-Terminus); SNCA; Alpha-synuclein; PARK4; PD1; Synuclein alpha-140; NACP; PARK1; aSynuclein; a-Synuclein; anti-SNCA antibody
Host
Rabbit
Reactivity
Chicken, Sheep, Mouse, Dog, Rat, Pig, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of Alpha-synuclein protein.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, pH7.3, 0.01% Sodium Azide, 30% Glycerol
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SNCA antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human SNCA/Alpha-Synuclein
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-Terminus of human Alpha-synuclein.
Conjugation
Unconjugated
Epitope
N-Terminus
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
IHC (Immunohistochemisry)
(SNCA/Alpha-Synuclein Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(SNCA/Alpha-Synuclein Antibody-Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(SNCA/Alpha-Synuclein Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(SNCA/Alpha-Synuclein Antibody-Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(SNCA/Alpha-Synuclein Antibody-Western blot analysis of Alpha-synuclein expression in A549 (A); SKNSH (B); PC12 (C) whole cell lysates.)
WB (Western Blot)
(SNCA/Alpha-Synuclein Antibody-Western blot analysis of Alpha-synuclein expression in A549 (A); SKNSH (B); PC12 (C) whole cell lysates.)
Related Product Information for anti-SNCA antibody
Alpha-Synuclein antibody is an unconjugated rabbit polyclonal antibody to Alpha-Synuclein (SNCA)(N-Terminus) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB.
SNCA (alpha-synuclein) is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA and aggregations of the protein as Lewy bodies/neurites are part of the pathogenesis of Parkinson disease, dementia, Alzheimer's disease and multiple system atrophy. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. In normal tissue, SNCA is expressed in presynaptic peripheral nerve terminals in the central nervous system, and has some positivity in bone marrow, the kidney, soft tissue and skin.
SNCA (alpha-synuclein) is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA and aggregations of the protein as Lewy bodies/neurites are part of the pathogenesis of Parkinson disease, dementia, Alzheimer's disease and multiple system atrophy. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. In normal tissue, SNCA is expressed in presynaptic peripheral nerve terminals in the central nervous system, and has some positivity in bone marrow, the kidney, soft tissue and skin.
References
Front Mol Neurosci. 2018; 11: 391, PMID: 30410434; Alzheimers Res Ther. 2014 Oct 27;6(5):73, PMID: 25580161; Parkinsons Dis. 2016; 2016: 1720621, PMID;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,460 Da
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Official Symbol
SNCA
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
NCBI Protein Information
alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
UniProt Protein Name
Alpha-synuclein
UniProt Gene Name
SNCA
UniProt Synonym Gene Names
NACP; PARK1; NACP
UniProt Entry Name
SYUA_HUMAN
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Product Notes
The SNCA snca (Catalog #AAA163100) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SNCA/Alpha-Synuclein Rabbit anti-Human Polyclonal (N-Terminus) Antibody reacts with Chicken, Sheep, Mouse, Dog, Rat, Pig, Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNCA/Alpha-Synuclein can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the SNCA snca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNCA/Alpha-Synuclein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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