WB (Western Blot)
(Western blot analysis of SOCS1 in human spleen tissue lysate with SOCS1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
Rabbit SOCS1 Polyclonal Antibody | anti-SOCS1 antibody
SOCS1 Antibody
Gene Names
SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1
Reactivity
Human, Mouse, Rat
Applications
Western Blot, ELISA
Purity
SOCS1 Antibody is affinity chromatography purified via peptide column.
Synonyms
SOCS1, Antibody; SOCS1 Antibody; SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; Suppressor of cytokine signaling 1; JAK-binding protein; suppressor of cytokine signaling 1; anti-SOCS1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
SOCS1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
211
Applicable Applications for anti-SOCS1 antibody
WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
SOCS1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human SOCS1.
Buffer
SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
SOCS1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
WB (Western Blot)
(Western blot analysis of SOCS1 in human spleen tissue lysate with SOCS1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
WB (Western Blot)
(Western blot analysis of SOCS1 in human spleen tissue lysate with SOCS1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
Related Product Information for anti-SOCS1 antibody
SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
23,551 Da
NCBI Official Full Name
suppressor of cytokine signalling protein
NCBI Official Synonym Full Names
suppressor of cytokine signaling 1
NCBI Official Symbol
SOCS1
NCBI Official Synonym Symbols
JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1
NCBI Protein Information
suppressor of cytokine signaling 1; TIP-3; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1
UniProt Protein Name
Suppressor of cytokine signaling 1
UniProt Gene Name
SOCS1
UniProt Synonym Gene Names
SSI1; TIP3; SOCS-1; JAB; SSI-1; TIP-3
UniProt Entry Name
SOCS1_HUMAN
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Product Notes
The SOCS1 socs1 (Catalog #AAA39843) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SOCS1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SOCS1 socs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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