Rabbit anti-Human, Mouse SREBF1 Polyclonal Antibody | anti-SREBF1 antibody

SREBF1 Antibody

Cat. Num. AAA40637

• Gene Names: SREBF1; SREBP1; bHLHd1; SREBP-1c
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: SREBF1 antibody is affinity chromatography purified via peptide column.
• Synonyms: SREBF1, Antibody; SREBF1 Antibody; SREBF1; SREBP1; bHLHd1; SREBP-1c; BHLHD1; Sterol regulatory element-binding protein 1; Class D basic helix-loop-helix protein 1; SREBP-1; sterol regulatory element binding transcription factor 1; anti-SREBF1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: SREBF1 antibody is human and mouse reactive. At least three isoforms of SREBF1 are known to exist. SREBF1 antibody is predicted not to cross-react with SREBF2.
• Purity/Purification: SREBF1 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1177

• Applicable Applications for anti-SREBF1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: SREBF1 antibody was raised against a 17 amino acid peptide near the center of human SREBF1.
• Buffer: SREBF1 antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SREBF1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of SREBF1 in human spleen tissue with SREBF1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of SREBF1 in human spleen tissue with SREBF1 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of SREBF1 in Daudi cell lysate with SREBF1 antibody at 1 μg/ml.)

Related Product Information for anti-SREBF1 antibody

The sterol regulatory element binding transcription factor 1 (SREBF1) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1). The related protein SREBF2 also binds SRE1 and activates transcription in an additive fashion to SREBF1 (2). SREBF1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1 (3). The SREBF1 proteins are important in the regulation of genes involved in lipid metabolism, while SREBF2 has been more closely associated with cholesterol synthesis and accumulation (4).

NCBI and Uniprot Product Information

• NCBI GI #: 52630419
• NCBI GeneID: 6720
• NCBI Accession #: NP_001005291
• NCBI GenBank Nucleotide #: NM_001005291.2
• UniProt Accession #: P36956; Q16062; Q59F52; Q6P4R7; Q6PFW7; Q6PJ36; Q8TAK9; B0I4X3; B0I4X4; D3DXC4
• Molecular Weight: Predicted: 129 kDa; ; Observed: 132 kDa
• NCBI Official Full Name: sterol regulatory element-binding protein 1 isoform a
• NCBI Official Synonym Full Names: sterol regulatory element binding transcription factor 1
• NCBI Official Symbol: SREBF1
• NCBI Official Synonym Symbols: SREBP1; bHLHd1; SREBP-1c
• NCBI Protein Information: sterol regulatory element-binding protein 1; SREBP-1; class D basic helix-loop-helix protein 1
• UniProt Protein Name: Sterol regulatory element-binding protein 1
• UniProt Gene Name: SREBF1
• UniProt Synonym Gene Names: BHLHD1; SREBP1; SREBP-1; bHLHd1
• UniProt Entry Name: SRBP1_HUMAN