IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded Human breast cancer using SRGAP1 Polyclonal Antibody at dilution of 1:25)
Rabbit SRGAP1 Polyclonal Antibody | anti-SRGAP1 antibody
SRGAP1 Polyclonal Antibody
Gene Names
SRGAP1; ARHGAP13
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Antigen affinity purification
Synonyms
SRGAP1, Antibody; SRGAP1 Polyclonal Antibody; ARHGAP13; anti-SRGAP1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1.6mg/mL (varies by lot)
Sequence Length
1085
Applicable Applications for anti-SRGAP1 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen
Synthetic peptide of human SRGAP1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded Human breast cancer using SRGAP1 Polyclonal Antibody at dilution of 1:25)
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded Human breast cancer using SRGAP1 Polyclonal Antibody at dilution of 1:25)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer using SRGAP1 Polyclonal Antibody at dilution of 1:25)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded Human liver cancer using SRGAP1 Polyclonal Antibody at dilution of 1:25)
WB (Western Blot)
(Western Blot analysis of Hepg2, TM4, 293T and NIH/3T3 cell using SRGAP1 Polyclonal Antibody at dilution of 1:200)
WB (Western Blot)
(Western Blot analysis of Hepg2, TM4, 293T and NIH/3T3 cell using SRGAP1 Polyclonal Antibody at dilution of 1:200)
Related Product Information for anti-SRGAP1 antibody
SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 ultimately leads to a decrease in actin polymerization.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
121,594 Da
NCBI Official Full Name
SLIT-ROBO Rho GTPase-activating protein 1
NCBI Official Synonym Full Names
SLIT-ROBO Rho GTPase activating protein 1
NCBI Official Symbol
SRGAP1
NCBI Official Synonym Symbols
ARHGAP13
NCBI Protein Information
SLIT-ROBO Rho GTPase-activating protein 1; rho GTPase-activating protein 13
UniProt Protein Name
SLIT-ROBO Rho GTPase-activating protein 1
UniProt Gene Name
SRGAP1
UniProt Synonym Gene Names
ARHGAP13; KIAA1304; srGAP1
UniProt Entry Name
SRGP1_HUMAN
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Product Notes
The SRGAP1 srgap1 (Catalog #AAA168403) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SRGAP1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SRGAP1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the SRGAP1 srgap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SRGAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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