Rabbit anti-Human TAB182 Polyclonal Antibody | anti-TAB182 antibody

Rabbit anti-TAB182 Antibody, Affinity Purified

Cat. Num. AAA211474

• Gene Names: TNKS1BP1; TAB182
• Reactivity: Human
• Applications: Immunoprecipitation, Western Blot
• Purity: Antigen Affinity Purified
• Synonyms: TAB182, Antibody; Rabbit anti-TAB182 Antibody, Affinity Purified; TAB182; testis secretory sperm-binding protein Li 206a; tankyrase 1 binding protein 1, 182kDa; 182 kDa tankyrase-1-binding protein; tankyrase 1-binding protein of 182 kDa; tankyrase 1 binding protein 1; anti-TAB182 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
• Concentration: 200ug/ml (varies by lot)

• Applicable Applications for anti-TAB182 antibody: IP (Immunoprecipitation), WB (Western Blot)
• Immunogen: Between 1679 and C-terminus
• Conjugation: Unconjugated
• Preparation and Storage: Store at 2-8 degree C; Shelf Life: 1 year from date of receipt

WB (Western Blot)

(Detection of human TAB182 by western blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-TAB182 antibody AAA211474 (lot AAA211474-2) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.)

IP (Immunoprecipitation)

(Detection of human TAB182 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-TAB182 antibody AAA211474 (lot AAA211474-2) used for IP at 6 ug per reaction. TAB182 was also immunoprecipitated by rabbit anti-TAB182 antibodies and For blotting immunoprecipitated TAB182, AAA211474 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.)

Related Product Information for anti-TAB182 antibody

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Product Categories/Family for anti-TAB182 antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 110556636
• NCBI GeneID: 85456
• NCBI Accession #: NP_203754.2
• NCBI GenBank Nucleotide #: NM_033396.2
• UniProt Accession #: Q9C0C2; Q6PJ35; Q6ZV74; A7E2F8
• Molecular Weight: 181,796 Da
• NCBI Official Full Name: 182 kDa tankyrase-1-binding protein
• NCBI Official Synonym Full Names: tankyrase 1 binding protein 1, 182kDa
• NCBI Official Symbol: TNKS1BP1
• NCBI Official Synonym Symbols: TAB182
• NCBI Protein Information: 182 kDa tankyrase-1-binding protein; tankyrase 1-binding protein of 182 kDa
• UniProt Protein Name: 182 kDa tankyrase-1-binding protein
• UniProt Gene Name: TNKS1BP1
• UniProt Synonym Gene Names: KIAA1741; TAB182
• UniProt Entry Name: TB182_HUMAN