Rabbit anti-Mouse TCPTP Polyclonal Antibody | anti-PTPN2 antibody

Anti-TCPTP Antibody, Rabbit Polyclonal

Cat. Num. AAA257228

• Gene Names: Ptpn2; Ptpt; TC-PTP; AI325124
• Reactivity: Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Protein A & Antigen Affinity
• Synonyms: TCPTP, Antibody; Anti-TCPTP Antibody, Rabbit Polyclonal; TCPTP/PTPN2 Antibody, Rabbit PAb, Antigen Affinity Purified; protein tyrosine phosphatase, non-receptor type 2; Anti-AI325124 Antibody; Anti-Ptpt Antibody; Anti-TC-PTP Antibody; anti-PTPN2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse TCPTP/PTPN2
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PTPN2 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant Mouse TCPTP/PTPN2 Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse TCPTP/PTPN2 (rM TCPTP/PTPN2). TCPTP/PTPN2 specific IgG was purified by Mouse TCPTP/PTPN2 affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

IHC (Immunohistochemisry)

(Immunochemical staining of mouse PTPN2 in mouse liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohiostchemistry)

(Immunochemical staining of mouse PTPN2 in mouse brain with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining of mouse PTPN2 in mouse kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PTPN2 antibody

Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase (PTP) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP/PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP/PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP/PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP/PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Product Categories/Family for anti-PTPN2 antibody

Phosphatases and Regulators

References

Cool D., et al., (1989), cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc. Natl. Acad. Sci. U.S.A. 86:5257-5261.Ota T., et al., (2004), Complete sequencing and characterization of 21, 243 full-length human cDNAs.Nat. Genet. 36:40-45.Nusbaum C., et al., (2005), DNA sequence and analysis of human chromosome 18.Nature 437:551-555.

NCBI and Uniprot Product Information

• NCBI GI #: 187608416
• NCBI GeneID: 19255
• NCBI Accession #: NP_001120649.1
• NCBI GenBank Nucleotide #: NM_001127177.1
• UniProt Accession #: Q06180; Q3V259; Q922E7
• Molecular Weight: 44,573 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 2 isoform b
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 2
• NCBI Official Symbol: Ptpn2
• NCBI Official Synonym Symbols: Ptpt; TC-PTP; AI325124
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 2
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 2
• UniProt Gene Name: Ptpn2
• UniProt Synonym Gene Names: Ptpt; Protein-tyrosine phosphatase PTP-2