Rabbit TDP43 Polyclonal Antibody | anti-TDP43 antibody

TDP43 Antibody

Cat. Num. AAA306083

• Reactivity: Human, Mouse, Rat
• Applications: Immunocytochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TDP43, Antibody; TDP43 Antibody; TAR DNA binding protein, TARDBP; anti-TDP43 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 416

• Applicable Applications for anti-TDP43 antibody: ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the amino terminus of human TDP43.
• Target Name: TDP43
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 ug/mL.)

WB (Western Blot)

(Western blot analysis of TDP43 in HeLa cell lysate with TDP43 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.)

Related Product Information for anti-TDP43 antibody

TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Product Categories/Family for anti-TDP43 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 130750552
• Molecular Weight: 31,808 Da
• NCBI Official Full Name: TDP43
• UniProt Protein Name: TAR DNA-binding protein 43
• UniProt Gene Name: TARDBP
• UniProt Synonym Gene Names: TDP43; TDP-43
• UniProt Entry Name: TADBP_HUMAN