IHC (Immunohiostchemistry)
(Immunohistochemistry: Human Placenta (FFPE) stained with Rabbit anti-TGFbR2 (Cat# AAA71300) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
Rabbit anti-Human TGF beta Receptor II Polyclonal Antibody | anti-TGFBR2 antibody
Rabbit anti TGF beta Receptor II Polyclonal Antibody
Gene Names
TGFBR2; AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
Reactivity
Human
Applications
Western Blot, Immunoprecipitation, Immunohistochemistry, ELISA
Purity
Purified by Epitope Affinity Purification
Synonyms
TGF beta Receptor II, Antibody; Rabbit anti TGF beta Receptor II Polyclonal Antibody; TGFBR2; Transforming Growth Factor beta Receptor II; anti-TGFBR2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody reacts with human TGF-beta Receptor II. The other species are not tested.
Purity/Purification
Purified by Epitope Affinity Purification
Form/Format
Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Sequence Length
567
Applicable Applications for anti-TGFBR2 antibody
WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA
Preparation
A synthetic peptide derived from internal sequence (90-160aa) of human TGFbeta receptor type-2. This sequence is also identical within human, rat, mouse, chicken, bovine species.
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at –20°C to –70°C. The antibodies can be stored at 2°C-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
IHC (Immunohiostchemistry)
(Immunohistochemistry: Human Placenta (FFPE) stained with Rabbit anti-TGFbR2 (Cat# AAA71300) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
IHC (Immunohiostchemistry)
(Immunohistochemistry: Human Placenta (FFPE) stained with Rabbit anti-TGFbR2 (Cat# AAA71300) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.)
WB (Western Blot)
(Western Blot: The cell lysate derived from HEK293 transfected with full length of TGF R1 was immunoprobed by Rabbit anti-TGF R2(Cat#AAA71300) at 1:500. An immunoreactive band is observed around ~65 kDa)
WB (Western Blot)
(Western Blot: The cell lysate derived from HEK293 transfected with full length of TGF R1 was immunoprobed by Rabbit anti-TGF R2(Cat#AAA71300) at 1:500. An immunoreactive band is observed around ~65 kDa)
Related Product Information for anti-TGFBR2 antibody
Background: Transforming growth factor ? isoforms (TGF-β1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal through a highly restricted subset of receptors known as TGF-β type I receptor (TβR-I) and TGF-β type II receptor (TβR-II). TGF-β's specificity for TβR-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-β and TβR-II. TGF-β binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF betabinding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in TβR-I and TβR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
65.0
NCBI Official Full Name
transforming growth factor beta receptor II
NCBI Official Synonym Full Names
transforming growth factor beta receptor 2
NCBI Official Symbol
TGFBR2
NCBI Official Synonym Symbols
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
NCBI Protein Information
TGF-beta receptor type-2
UniProt Protein Name
TGF-beta receptor type-2
UniProt Gene Name
TGFBR2
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II
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Product Notes
The TGFBR2 tgfbr2 (Catalog #AAA71300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti TGF beta Receptor II Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TGF beta Receptor II can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the TGFBR2 tgfbr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGF beta Receptor II, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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