IHC (Immunohiostchemistry)
(Immunohistochemistry of THEM4 in human liver tissue with THEM4 antibody at 2.5 ug/mL.)
Rabbit THEM4 Polyclonal Antibody | anti-THEM4 antibody
THEM4 Antibody
Gene Names
THEM4; CTMP
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
THEM4, Antibody; THEM4 Antibody; Thioesterase superfamily member 4, Carboxy-terminal modulator protein, CTMP; anti-THEM4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
240
Applicable Applications for anti-THEM4 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against an 18 amino acid peptide near the center of human THEM4.
Target Name
THEM4
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of THEM4 in human liver tissue with THEM4 antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of THEM4 in human liver tissue with THEM4 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/mL.)
WB (Western Blot)
(Western blot analysis of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-THEM4 antibody
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
Product Categories/Family for anti-THEM4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,130 Da
NCBI Official Full Name
acyl-coenzyme A thioesterase THEM4
NCBI Official Synonym Full Names
thioesterase superfamily member 4
NCBI Official Symbol
THEM4
NCBI Official Synonym Symbols
CTMP
NCBI Protein Information
acyl-coenzyme A thioesterase THEM4
UniProt Protein Name
Acyl-coenzyme A thioesterase THEM4
UniProt Gene Name
THEM4
UniProt Synonym Gene Names
CTMP; Acyl-CoA thioesterase THEM4
UniProt Entry Name
THEM4_HUMAN
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Product Notes
The THEM4 them4 (Catalog #AAA305493) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The THEM4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's THEM4 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the THEM4 them4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "THEM4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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