Rabbit anti-Human, Mouse TNAP3 Polyclonal Antibody | anti-TNAP3 antibody

TNAP3 Antibody

Cat. Num. AAA305163

• Gene Names: TNFAIP3; A20; OTUD7C; TNFA1P2
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TNAP3, Antibody; TNAP3 Antibody; A20; DNA binding protein A20; EC 3.-.-.-; TNAP3; TNFA1P2; anti-TNAP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total TNAP3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 790

• Applicable Applications for anti-TNAP3 antibody: IF (Immunofluorescence), WB (Western Blot)
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human TNAP3.
• Target Name: TNAP3
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of HepG2 cells, using TNAP3 antibody.)

WB (Western Blot)

(Western blot analysis of extracts from RAW264.7 cells, using TNAP3 antibody.)

Related Product Information for anti-TNAP3 antibody

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.Opipari A.W. Jr., J. Biol. Chem. 265:14705-14708(1990).Mungall A.J., Nature 425:805-811(2003).Eliopoulos A.G., J. Virol. 73:1023-1035(1999).

Product Categories/Family for anti-TNAP3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 395393995
• NCBI GeneID: 7128
• NCBI Accession #: NP_001257436.1
• NCBI GenBank Nucleotide #: NM_001270507.1
• UniProt Accession #: P21580; Q2HIX9; Q5VXQ7; Q9NSR6; B2R767; E1P588
• Molecular Weight: 89,614 Da
• NCBI Official Full Name: tumor necrosis factor alpha-induced protein 3
• NCBI Official Synonym Full Names: tumor necrosis factor, alpha-induced protein 3
• NCBI Official Symbol: TNFAIP3
• NCBI Official Synonym Symbols: A20; OTUD7C; TNFA1P2
• NCBI Protein Information: tumor necrosis factor alpha-induced protein 3
• UniProt Protein Name: Tumor necrosis factor alpha-induced protein 3
• UniProt Gene Name: TNFAIP3
• UniProt Synonym Gene Names: OTUD7C; TNF alpha-induced protein 3
• UniProt Entry Name: TNAP3_HUMAN