Rabbit TNFAIP1 Polyclonal Antibody | anti-TNFAIP1 antibody

TNFAIP1 Antibody

Cat. Num. AAA40834

• Gene Names: TNFAIP1; B12; B61; EDP1; BTBD34; hBACURD2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column.
• Synonyms: TNFAIP1, Antibody; TNFAIP1 Antibody; Tumor necrosis factor, alpha-induced protein 1, BTB/POZ domain-containing protein TNFAIP1,BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BACURD2, EDP1; anti-TNFAIP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.
• Purity/Purification: Affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 316

• Applicable Applications for anti-TNFAIP1 antibody: IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Immunogen: TNFAIP1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TNFAIP1.
• Buffer: Supplied in PBS containing 0.02% sodium azide.
• Positive Control 1: Mouse Brain Tissue Lysate
• Conjugate: Unconjugated
• Preparation and Storage: Store at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of TNFAIP1 in mouse brain tissue with TNFAIP1 antibody at 20 μg/ml.Red: TNFAIP1 Antibody (8345)Blue: DAPI staining)

IHC (Immunohiostchemistry)

(Immunohistochemistry of TNFAIP1 in mouse brain tissue with TNFAIP1 antibody at 10 μg/ml.)

WB (Western Blot)

(Western blot analysis of TNFAIP1 in mouse brain tissue lysate with TNFAIP1 antibody at 1 μg/ml.)

Related Product Information for anti-TNFAIP1 antibody

TNFAIP1 is a BTB/POZ domain-containing protein that belongs to the KCTD10/BACURD family which mediates POZ-POZ interactions and chromatin modeling (1,2). The expression of TNFAIP1 is developmentally regulated in a tissue-specific manner and can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells (3). TNFAIP1 may be involved in DNA repair, DNA synthesis, and cell apoptosis. TNFAIP1 is suggested to play a role in the process of cancer and in the innate immunity against the Hepatitis B virus (4,5).

Product Categories/Family for anti-TNFAIP1 antibody

Apoptosis; Cancer; Innate Immunity

References

Liu M, Sun Z, Zhou A, et al. Functional characterization of the promoter region of human TNFAIP1 gene. Mol. Biol. Rep. 2010; 37:1699-705. Hu X, Yan F, Wang F, et al. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kappaB and AP-1. Mol. Biol. Rep. 2012; 39:9911-9. Zhang CL, Wang C, Yan WJ, et al. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-?B pathway. Oncol. Rep. 2014; 32:1149-55. Kim DM, Chung KS, Choi SJ, et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int. J. Cancer 2009; 125:2520-7.

NCBI and Uniprot Product Information

• NCBI GI #: 10863937
• NCBI GeneID: 7126
• NCBI Accession #: NP_066960
• NCBI GenBank Nucleotide #: NM_021137.4
• UniProt Accession #: Q13829; Q5TZQ1; B7Z6M4
• Molecular Weight: Predicted: 35 kDa; Observed: 35 kDa
• NCBI Official Full Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
• NCBI Official Synonym Full Names: TNF alpha induced protein 1
• NCBI Official Symbol: TNFAIP1
• NCBI Official Synonym Symbols: B12; B61; EDP1; BTBD34; hBACURD2
• NCBI Protein Information: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
• UniProt Protein Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
• UniProt Gene Name: TNFAIP1
• UniProt Synonym Gene Names: BACURD2; EDP1; hBACURD2
• UniProt Entry Name: BACD2_HUMAN