Rabbit anti-Human, Mouse TNIK Polyclonal Antibody | anti-TNIK antibody

TNIK (S764) Antibody

Cat. Num. AAA290926

• Gene Names: TNIK; MRT54
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Purified through a protein A column, followed by peptide affinity purification.
• Synonyms: TNIK, Antibody; TNIK (S764) Antibody; TRAF2 and NCK-interacting protein kinase; 2.7.11.1; TNIK; KIAA0551; anti-TNIK antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This TNIK(S764) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human TNIK(S764).
• Purity/Purification: Purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Length: 1352

• Applicable Applications for anti-TNIK antibody: ELISA, WB (Western Blot)
• Antigen Type: Synthesized Peptide
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Dilution: WB - 1:500All lanes: Anti-TNIK(S764) Antibody at 1:500 dilution Lane 1: Human brain lysate Lane 2: Caco2 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 155 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)

WB (Western Blot)

(Dilution: WB - 1:500All lanes: Anti-TNIK(S764) Antibody at 1:500 dilution Lane 1: Human brain tissue lysate Lane 2: Caco2 whole cell lysate Lane 3: U-2 OS whole cell lysate Lane 4: U-251 MG whole cell lysate Lane 5: Mouse brain tissue lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 155 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-TNIK antibody

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Product Categories/Family for anti-TNIK antibody

Signal Transduction

References

Fu C.A.,et al.J. Biol. Chem. 274:30729-30737(1999). Nagase T.,et al.DNA Res. 5:31-39(1998). Nakajima D.,et al.DNA Res. 9:99-106(2002). Ota T.,et al.Nat. Genet. 36:40-45(2004). Muzny D.M.,et al.Nature 440:1194-1198(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 239735580
• NCBI GeneID: 23043
• NCBI Accession #: NP_001155032.1
• NCBI GenBank Nucleotide #: NM_001161560.2
• UniProt Accession #: Q9UKE5
• Molecular Weight: 154943 Da
• NCBI Official Full Name: TRAF2 and NCK-interacting protein kinase isoform 2
• NCBI Official Synonym Full Names: TRAF2 and NCK interacting kinase
• NCBI Official Symbol: TNIK
• NCBI Official Synonym Symbols: MRT54
• NCBI Protein Information: TRAF2 and NCK-interacting protein kinase
• UniProt Protein Name: TRAF2 and NCK-interacting protein kinase
• UniProt Gene Name: TNIK
• UniProt Synonym Gene Names: KIAA0551
• UniProt Entry Name: TNIK_HUMAN