WB (Western Blot)
(Western blot analysis of extracts from mouse spleen, using TPOR Antibody. The lane on the left was treated with blocking peptide.)
Rabbit TPOR Polyclonal Antibody | anti-TPOR antibody
TPOR Antibody
Gene Names
MPL; MPLV; TPOR; C-MPL; CD110; THCYT2
Reactivity
Human, Mouse, RatPredicted Reactivity: Bovine (92%), Sheep (92%)
Applications
ELISA, Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
Synonyms
TPOR, Antibody; TPOR Antibody; C MPL; CD110; mpl; MPLV; Myeloproliferative leukemia protein; Myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; THCYT2; Thrombopoietin receptor; TPO R; TPO-R; TPOR; TPOR_HUMAN; anti-TPOR antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted Reactivity: Bovine (92%), Sheep (92%)
Predicted Reactivity: Bovine (92%), Sheep (92%)
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TPOR Antibody detects endogenous levels of total TPOR.
Tissue Specificity: Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Tissue Specificity: Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TPOR antibody
ELISA (Peptide ELISA), WB (Western Blot)
Immunogen
A synthesized peptide derived from human TPOR, corresponding to a region within C-terminal amino acids.
Conjugation
Unconjugated
Fragment
Fab fragment
Post Translational Modifications
Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
Subunit Structure
Homodimer. Interacts with ATXN2L.
Similarity
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.Belongs to the type I cytokine receptor family. Type 1 subfamily.
Subcellular Location
Cell membrane>Single-pass type I membrane protein. Golgi apparatus. Cell surface.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of extracts from mouse spleen, using TPOR Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from mouse spleen, using TPOR Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from COLO205 cells, using TPOR Antibody. The lane on the left was treated with blocking peptide.)
WB (Western Blot)
(Western blot analysis of extracts from COLO205 cells, using TPOR Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-TPOR antibody
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65,521 Da
NCBI Official Full Name
thrombopoietin receptor
NCBI Official Synonym Full Names
MPL proto-oncogene, thrombopoietin receptor
NCBI Official Symbol
MPL
NCBI Official Synonym Symbols
MPLV; TPOR; C-MPL; CD110; THCYT2
NCBI Protein Information
thrombopoietin receptor; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene
UniProt Protein Name
Thrombopoietin receptor
UniProt Gene Name
MPL
UniProt Synonym Gene Names
TPOR; TPO-R
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Product Notes
The TPOR mpl (Catalog #AAA329542) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TPOR Antibody reacts with Human, Mouse, Rat Predicted Reactivity: Bovine (92%), Sheep (92%) and may cross-react with other species as described in the data sheet. AAA Biotech's TPOR can be used in a range of immunoassay formats including, but not limited to, ELISA (Peptide ELISA), WB (Western Blot). Researchers should empirically determine the suitability of the TPOR mpl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPOR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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