Application Data
(DYKDDDDK-tagged TREM2 transfected COS cells showing TREM2 (Cat.#AAA72836, 1:150) staining in red and DYKDDDDK staining in green causing positive transfected cells to appear yellow. DNA is stained blue with DAPI.)
Rabbit TREM2 Polyclonal Antibody | anti-TREM2 antibody
TREM2
Gene Names
TREM2; TREM-2; Trem2a; Trem2b; Trem2c
Reactivity
Reactivity assumed based on 100% sequence homology: Human
Applications
Immunocytochemistry, Western Blot
Purity
Antigen Affinity Purified from Pooled Serum
Synonyms
TREM2, Antibody; TREM2; anti-TREM2 antibody
Host
Rabbit
Reactivity
Reactivity assumed based on 100% sequence homology: Human
Clonality
Polyclonal
Purity/Purification
Antigen Affinity Purified from Pooled Serum
Form/Format
100ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100ug BSA per ml and 50% glycerol.
Applicable Applications for anti-TREM2 antibody
ICC (Immunocytochemistry), WB (Western Blot)
Species Positively Tested
Mouse
Immunogen Species
Human
Immunogen Information
Recombinant human TREM2 fusion protein expressed in and purified from E Coli
Antigen
Recombinant human TREM2 protein expressed in and purified from E Coli.
Preparation and Storage
Storage at -20 degree C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20 degree C.
Shipping: Blue Ice
Country of Origin: USA
Shipping: Blue Ice
Country of Origin: USA
Application Data
(DYKDDDDK-tagged TREM2 transfected COS cells showing TREM2 (Cat.#AAA72836, 1:150) staining in red and DYKDDDDK staining in green causing positive transfected cells to appear yellow. DNA is stained blue with DAPI.)
Application Data
(DYKDDDDK-tagged TREM2 transfected COS cells showing TREM2 (Cat.#AAA72836, 1:150) staining in red and DYKDDDDK staining in green causing positive transfected cells to appear yellow. DNA is stained blue with DAPI.)
WB (Western Blot)
(Western blot of mouse whole brain lysate showing specific immunolabeling of the ~28 kDa TREM2 protein.)
WB (Western Blot)
(Western blot of mouse whole brain lysate showing specific immunolabeling of the ~28 kDa TREM2 protein.)
Related Product Information for anti-TREM2 antibody
Triggering receptor expressed on myeloid cells 2, TREM2, is a type I transmembrane innate immune receptor predominantly expressed by microglia in the central nervous system and is genetically linked to the risk for Alzheimer's disease (Schmid, C.D., et al., 2002). TREM2 has been shown to be a specific marker for alternatively activated microglia known as M2 cells (Cherry, J.D. et al., 2014). TREM2 binds to its adaptor, DNAX-activating protein (DAP12) on the surface of microglia to enact innate immune responses and downstream cellular responses or signaling pathways (Jay,T.R, et al., 2017). TREM2 has important roles in microglial phagocytosis of apoptotic neurons, damaged myelin, and amyloid plaques (Gratuze, M., et al., 2018). In early brain development, TREM2 is essential for synaptic pruning (Filipello, F. et al., 2018).
Product Categories/Family for anti-TREM2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24,669 Da
NCBI Official Full Name
triggering receptor expressed on myeloid cells 2 isoform 1
NCBI Official Synonym Full Names
triggering receptor expressed on myeloid cells 2
NCBI Official Symbol
TREM2
NCBI Official Synonym Symbols
TREM-2; Trem2a; Trem2b; Trem2c
NCBI Protein Information
triggering receptor expressed on myeloid cells 2
UniProt Protein Name
Triggering receptor expressed on myeloid cells 2
UniProt Gene Name
TREM2
UniProt Synonym Gene Names
TREM-2
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Product Notes
The TREM2 trem2 (Catalog #AAA72836) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TREM2 reacts with Reactivity assumed based on 100% sequence homology: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TREM2 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the TREM2 trem2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TREM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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