Rabbit TREX1 Polyclonal Antibody | anti-TREX1 antibody

TREX1 Antibody

Cat. Num. AAA39671

• Gene Names: TREX1; CRV; AGS1; DRN3; HERNS
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: TREX1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TREX1, Antibody; TREX1 Antibody; TREX1; CRV; AGS1; DRN3; HERNS; Three prime repair exonuclease 1; DNase III; three prime repair exonuclease 1; anti-TREX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TREX1 antibody will not cross-react with the related protein TREX2.
• Purity/Purification: TREX1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 369

• Applicable Applications for anti-TREX1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: TREX1 antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1.
• Buffer: TREX1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TREX1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of TREX1 in Human Spleen tissue with TREX1 antibody at 20 μgg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of TREX1 in human spleen tissue with TREX1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 antibody at (A) 0.5 and (B) 1 μg/mL.)

Related Product Information for anti-TREX1 antibody

TREX1 Antibody: Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

NCBI and Uniprot Product Information

• NCBI GI #: 7705353
• NCBI GeneID: 11277
• NCBI Accession #: NP_057465
• NCBI GenBank Nucleotide #: NM_016381.5
• UniProt Accession #: Q9NSU2; Q8TEU2; Q9BPW1; Q9Y4X2; B2RCN9
• Molecular Weight: 33,212 Da
• NCBI Official Full Name: three-prime repair exonuclease 1 isoform a
• NCBI Official Synonym Full Names: three prime repair exonuclease 1
• NCBI Official Symbol: TREX1
• NCBI Official Synonym Symbols: CRV; AGS1; DRN3; HERNS
• NCBI Protein Information: three-prime repair exonuclease 1; DNase III; deoxyribonuclease III; 3' repair exonuclease 1; 3'-5' exonuclease TREX1
• UniProt Protein Name: Three-prime repair exonuclease 1
• UniProt Gene Name: TREX1
• UniProt Entry Name: TREX1_HUMAN