WB (Western Blot)
(Western blot analysis of Phospho-Trk C (Tyr705) in lysates of HeLa serum 20% 15', using Phospho-Trk C (Tyr705) Antibody.)
Rabbit Trk C Polyclonal Antibody | anti-Trk C antibody
Phospho-Trk C (Tyr705) Antibody
Gene Names
NTRK3; TRKC; GP145-TrkC; gp145(trkC)
Reactivity
Human, Mouse, Rat, MonkeyPredicted: Pig, Bovine, Horse, Chicken
Applications
ELISA, Immunohistochemistry, Western Blot
Purity
Purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Synonyms
Trk C, Antibody; Phospho-Trk C (Tyr705) Antibody; EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion; GP145 TrkC; gp145(trkC); GP145-TrkC; GP145TrkC; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor; NT 3 growth factor receptor; NT 3 growth factor receptor precursor; NT 3 receptor; NT-3 growth factor receptor; Ntrk3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; Trk-C; TRKC; TrkC tyrosine kinase; Tyrosine kinase receptor C; anti-Trk C antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Predicted: Pig, Bovine, Horse, Chicken
Predicted: Pig, Bovine, Horse, Chicken
Clonality
Polyclonal
Isotype
IgG
Specificity
Phospho-Trk C (Tyr705) Antibody detects endogenous levels of Trk C only when phosphorylated at Tyr705.
Purity/Purification
Purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
839
Applicable Applications for anti-Trk C antibody
ELISA (Peptide ELISA), IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthesized peptide derived from human Trk C around the phosphorylation site of Tyr705.
Tissue Specificity
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Conjugate
Unconjugated
Subcellular Location
Membrane
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of Phospho-Trk C (Tyr705) in lysates of HeLa serum 20% 15', using Phospho-Trk C (Tyr705) Antibody.)
WB (Western Blot)
(Western blot analysis of Phospho-Trk C (Tyr705) in lysates of HeLa serum 20% 15', using Phospho-Trk C (Tyr705) Antibody.)
WB (Western Blot)
(Western blot analysis of extracts from various samples, using Phospho-Trk C (Tyr705) Antibody.Lane 1: COS-7 uv treated, treated with blocking peptide;Lane 2: COS-7 uv treated;Lane 3: VERO heat shock treated.)
WB (Western Blot)
(Western blot analysis of extracts from various samples, using Phospho-Trk C (Tyr705) Antibody.Lane 1: COS-7 uv treated, treated with blocking peptide;Lane 2: COS-7 uv treated;Lane 3: VERO heat shock treated.)
IHC (Immunohistochemistry)
(At 1/100 staining rat lung tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary)
IHC (Immunohistochemistry)
(At 1/100 staining rat lung tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary)
Related Product Information for anti-Trk C antibody
Description: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Post Translational Modifications: Ligand-mediated auto-phosphorylation.
Subunit Structure: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546).
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Post Translational Modifications: Ligand-mediated auto-phosphorylation.
Subunit Structure: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546).
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 94 kDa
Predicted: 95 kDa
Predicted: 95 kDa
NCBI Official Full Name
NT-3 growth factor receptor isoform a
NCBI Official Synonym Full Names
neurotrophic receptor tyrosine kinase 3
NCBI Official Symbol
NTRK3
NCBI Official Synonym Symbols
TRKC; GP145-TrkC; gp145(trkC)
NCBI Protein Information
NT-3 growth factor receptor
UniProt Protein Name
NT-3 growth factor receptor
UniProt Gene Name
NTRK3
UniProt Synonym Gene Names
TRKC; Trk-C
UniProt Entry Name
NTRK3_HUMAN
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Product Notes
The Trk C ntrk3 (Catalog #AAA328528) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-Trk C (Tyr705) Antibody reacts with Human, Mouse, Rat, Monkey Predicted: Pig, Bovine, Horse, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's Trk C can be used in a range of immunoassay formats including, but not limited to, ELISA (Peptide ELISA), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the Trk C ntrk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Trk C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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