WB (Western Blot)
(Western blot analysis of TSC2 in Jurkat cell lysate with TSC2 antibody at (A) 1 and (B) 2 μg/mL..)
Rabbit anti-Human, Mouse TSC2 Polyclonal Antibody | anti-TSC2 antibody
TSC2 Antibody
Gene Names
TSC2; LAM; TSC4; PPP1R160
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
TSC2 Antibody is affinity chromatography purified via peptide column.
Synonyms
TSC2, Antibody; TSC2 Antibody; TSC2; LAM; TSC4; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis 2; anti-TSC2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
TSC2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
1807
Applicable Applications for anti-TSC2 antibody
WB (Western Blot), ELISA
Conjugate
Unconjugated
Immunogen
TSC2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human TSC2.
Buffer
TSC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TSC2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
WB (Western Blot)
(Western blot analysis of TSC2 in Jurkat cell lysate with TSC2 antibody at (A) 1 and (B) 2 μg/mL..)
WB (Western Blot)
(Western blot analysis of TSC2 in Jurkat cell lysate with TSC2 antibody at (A) 1 and (B) 2 μg/mL..)
WB (Western Blot)
(Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.)
WB (Western Blot)
(Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.)
Related Product Information for anti-TSC2 antibody
TSC2 Antibody: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,773 Da
NCBI Official Full Name
tuberin isoform 1
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
TSC2
NCBI Official Synonym Symbols
LAM; TSC4; PPP1R160
NCBI Protein Information
tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160
UniProt Protein Name
Tuberin
UniProt Gene Name
TSC2
UniProt Synonym Gene Names
TSC4
UniProt Entry Name
TSC2_HUMAN
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Product Notes
The TSC2 tsc2 (Catalog #AAA40222) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSC2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TSC2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the TSC2 tsc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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