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WB (Western Blot)
(Figure 1. Western blot analysis of TTK using anti-TTK antibody.)
Rabbit TTK/Mps1/TTK Polyclonal Antibody | anti-TTK antibody
Anti-TTK/Mps1/TTK Antibody
Gene Names
TTK; ESK; PYT; CT96; MPH1; MPS1; MPS1L1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Flow Cytometry, Functional Assay, Immunofluorescence, Immunocytochemistry, Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
TTK/Mps1/TTK, Antibody; Anti-TTK/Mps1/TTK Antibody; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT; TTK; MPS1, MPS1L1; anti-TTK antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
856
Applicable Applications for anti-TTK antibody
ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
E Coli-derived human TTK/Mps1/TTK recombinant protein (Position: Q487-S821).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Figure 1. Western blot analysis of TTK using anti-TTK antibody.)
WB (Western Blot)
(Figure 1. Western blot analysis of TTK using anti-TTK antibody.)
IHC (Immunohistochemistry)
IHC (Immunohistochemistry)
IHC (Immunohistochemisry)
IHC (Immunohistochemisry)
IF (Immunofluorescence)
IF (Immunofluorescence)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
Related Product Information for anti-TTK antibody
Description: Rabbit IgG polyclonal antibody for TTK/Mps1/TTK detection. Tested with WB, IHC-P, ICC/IF, FCM, Direct ELISA in Human; Mouse; Rat.
Background: Dual specificity protein kinase TTK is a protein that in humans is encoded by the XRCC2 gene. This gene is mapped to 6q14.1. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Background: Dual specificity protein kinase TTK is a protein that in humans is encoded by the XRCC2 gene. This gene is mapped to 6q14.1. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
References
1. Lindberg, R. A., Fischer, W. H., Hunter, T. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. Oncogene 8: 351-359, 1993.
2. Mills, G. B., Schmandt, R., McGill, M., Amendola, A., Hill, M., Jacobs, K., May, C., Rodricks, A.-M., Campbell, S., Hogg, D. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. J. Biol. Chem. 267: 16000-16006, 1992.
3. Poss, K. D., Wilson, L. G., Keating, M. T. Heart regeneration in zebrafish. Science 298: 2188-2190, 2002.
2. Mills, G. B., Schmandt, R., McGill, M., Amendola, A., Hill, M., Jacobs, K., May, C., Rodricks, A.-M., Campbell, S., Hogg, D. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. J. Biol. Chem. 267: 16000-16006, 1992.
3. Poss, K. D., Wilson, L. G., Keating, M. T. Heart regeneration in zebrafish. Science 298: 2188-2190, 2002.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
dual specificity protein kinase TTK isoform 2
NCBI Official Synonym Full Names
TTK protein kinase
NCBI Official Symbol
TTK
NCBI Official Synonym Symbols
ESK; PYT; CT96; MPH1; MPS1; MPS1L1
NCBI Protein Information
dual specificity protein kinase TTK
UniProt Protein Name
Dual specificity protein kinase TTK
UniProt Gene Name
TTK
UniProt Synonym Gene Names
MPS1; MPS1L1; PYT
UniProt Entry Name
TTK_HUMAN
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Product Notes
The TTK ttk (Catalog #AAA125416) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TTK/Mps1/TTK Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TTK/Mps1/TTK can be used in a range of immunoassay formats including, but not limited to, ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the TTK ttk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TTK/Mps1/TTK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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