IHC (Immunohiostchemistry)
(TYRP1/gp75 Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Mouse, Human TYRP1/gp75 Polyclonal Antibody | anti-TYRP1 antibody
TYRP1/gp75 Rabbit anti-Human Polyclonal (aa396-445) Antibody
Gene Names
TYRP1; TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
Reactivity
Mouse, Human
Applications
Western Blot, Immunohistochemistry, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
TYRP1/gp75, Antibody; TYRP1/gp75 Rabbit anti-Human Polyclonal (aa396-445) Antibody; PathPlus TYRP1/gp75 Antibody (aa396-445); TYRP1; B-PROTEIN; CAS2; CATB; Glycoprotein 75; Hstyrrp; gp75; OCA3; SHEP11; TRP-1; Tyrosinase-related protein 1; TYRP; TYRRP; Catalase B; DHICA oxidase; Melanoma antigen gp75; anti-TYRP1 antibody
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human TYRP1
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.09% sodium azide, 2% sucrose
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-TYRP1 antibody
WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human TYRP1/gp75
Immunogen
Synthetic peptide located between aa396-445 of human TYRP1 (P17643, NP_000541). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Sheep, Goat, Panda, Dog, Cat, Bat, Rabbit, Horse, Guinea pig, Chicken, Platypus (100%); Elephant, Bovine, Pig, Opossum, Zebra finch, Lizard (92%); Xenopus (85%); Pufferfish, Zebrafish (83%).
Conjugation
Unconjugated
Epitope
aa396-445
Preparation and Storage
Short term: Store at 2-8 degree C. Long term: Aliquot and store at -20 degree C. Avoid freeze/thaw cycles.
IHC (Immunohiostchemistry)
(TYRP1/gp75 Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(TYRP1/gp75 Antibody-Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(TYRP1/gp75 Antibody-Western blot of 721_B Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(TYRP1/gp75 Antibody-Western blot of 721_B Cell Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Related Product Information for anti-TYRP1 antibody
Gp75 antibody is an unconjugated rabbit polyclonal antibody to gp75 (TYRP1)(aa396-445) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB. Cited in 1 publication.
TYRP1 is a melanocyte-specific protein involved in melanin synthesis. It functions to stabilize tyrosinase protein and modulate its catalytic activity. It also plays a role in the maintenance of melanosome structure and influences melanocyte proliferation and cell death. Mutations in this gene are associated with oculocutaneous albinism type 3 (OCA3). Expression of this protein in metastatic melanoma correlates with Breslow thickness and poor prognosis, and it may be an effective target of inhibition therapy. In immunohistochemistry of normal tissue, it has membranous positivity on melanocytes.
TYRP1 is a melanocyte-specific protein involved in melanin synthesis. It functions to stabilize tyrosinase protein and modulate its catalytic activity. It also plays a role in the maintenance of melanosome structure and influences melanocyte proliferation and cell death. Mutations in this gene are associated with oculocutaneous albinism type 3 (OCA3). Expression of this protein in metastatic melanoma correlates with Breslow thickness and poor prognosis, and it may be an effective target of inhibition therapy. In immunohistochemistry of normal tissue, it has membranous positivity on melanocytes.
References
Pigment Cell Res. 2001 Dec;14(6):437-44, PMID: 11775055; Br J Cancer. 2011 Nov 22; 105(11): 1726 -1732, PMID: 22045183
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase related protein 1
NCBI Official Symbol
TYRP1
NCBI Official Synonym Symbols
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Gene Name
TYRP1
UniProt Synonym Gene Names
CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1
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Product Notes
The TYRP1 tyrp1 (Catalog #AAA162504) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TYRP1/gp75 Rabbit anti-Human Polyclonal (aa396-445) Antibody reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's TYRP1/gp75 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TYRP1 tyrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TYRP1/gp75, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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