IHC (Immunohiostchemistry)
(UMOD Antibody (Center) (AAA286594)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UMOD Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human UMOD Polyclonal Antibody | anti-UMOD antibody
UMOD Antibody (Center)
Gene Names
UMOD; THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
UMOD, Antibody; UMOD Antibody (Center); Uromodulin; Tamm-Horsfall urinary glycoprotein; THP; secreted form; UMOD; anti-UMOD antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This UMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from the Central region of human UMOD.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
352-380
Sequence Length
673
Applicable Applications for anti-UMOD antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(UMOD Antibody (Center) (AAA286594)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UMOD Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(UMOD Antibody (Center) (AAA286594)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UMOD Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(UMOD Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the UMOD antibody detected the UMOD protein (arrow).)
WB (Western Blot)
(UMOD Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the UMOD antibody detected the UMOD protein (arrow).)
Related Product Information for anti-UMOD antibody
This gene encodes uromodulin, the most abundant protein in
normal urine. Its excretion in urine follows proteolytic cleavage
of the ectodomain of its glycosyl phosphatidylinosital-anchored
counterpart that is situated on the luminal cell surface of the
loop of Henle. Uromodulin may act as a constitutive inhibitor of
calcium crystallization in renal fluids. Excretion of uromodulin in
urine may provide defense against urinary tract infections caused
by uropathogenic bacteria. Defects in this gene are associated with
the autosomal dominant renal disorders medullary cystic kidney
disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy
(FJHN). These disorders are characterized by juvenile onset of
hyperuricemia, gout, and progressive renal failure. While several
transcript variants may exist for this gene, the full-length
natures of only two have been described to date. These two
represent the major variants of this gene and encode the same
isoform.
normal urine. Its excretion in urine follows proteolytic cleavage
of the ectodomain of its glycosyl phosphatidylinosital-anchored
counterpart that is situated on the luminal cell surface of the
loop of Henle. Uromodulin may act as a constitutive inhibitor of
calcium crystallization in renal fluids. Excretion of uromodulin in
urine may provide defense against urinary tract infections caused
by uropathogenic bacteria. Defects in this gene are associated with
the autosomal dominant renal disorders medullary cystic kidney
disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy
(FJHN). These disorders are characterized by juvenile onset of
hyperuricemia, gout, and progressive renal failure. While several
transcript variants may exist for this gene, the full-length
natures of only two have been described to date. These two
represent the major variants of this gene and encode the same
isoform.
Product Categories/Family for anti-UMOD antibody
References
Mollsten, A., et al. Scand. J. Urol. Nephrol. 44(6):438-444(2010)
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Gudbjartsson, D.F., et al. PLoS Genet. 6 (7), E1001039 (2010) :
Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Gudbjartsson, D.F., et al. PLoS Genet. 6 (7), E1001039 (2010) :
Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
69761
NCBI Official Full Name
uromodulin isoform a preproprotein
NCBI Official Synonym Full Names
uromodulin
NCBI Official Symbol
UMOD
NCBI Official Synonym Symbols
THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2
NCBI Protein Information
uromodulin
UniProt Protein Name
Uromodulin
UniProt Gene Name
UMOD
UniProt Synonym Gene Names
THP
UniProt Entry Name
UROM_HUMAN
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Product Notes
The UMOD umod (Catalog #AAA286594) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 352-380. The UMOD Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UMOD can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the UMOD umod for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UMOD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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