Rabbit VISA Polyclonal Antibody | anti-MAVS antibody

VISA Antibody

Cat. Num. AAA40001

• Gene Names: MAVS; IPS1; VISA; IPS-1; CARDIF
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: VISA Antibody is affinity chromatography purified via peptide column.
• Synonyms: VISA, Antibody; VISA Antibody; VISA; IPS1; IPS-1; CARDIF; KIAA1271; Mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; MAVS; mitochondrial antiviral signaling protein; anti-MAVS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: VISA Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 540

• Applicable Applications for anti-MAVS antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: VISA antibody was raised against a 17 amino acid synthetic peptide from near the center of human VISA.
• Buffer: VISA Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: VISA antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of VISA in Mouse Brain cells with VISA antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of VISA in mouse brain tissue with VISA antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of VISA in rat brain tissue lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)

Related Product Information for anti-MAVS antibody

VISA Antibody: Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-κB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKα, IKKβ and IKKε kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 83776598
• NCBI GeneID: 57506
• NCBI Accession #: NP_065797
• NCBI GenBank Nucleotide #: NM_020746.4
• UniProt Accession #: Q7Z434; Q2HWT5; Q3I0Y2; Q5T7I6; Q86VY7; Q9H1H3; Q9H4Y1; A8K6X0; B2BD33; B2BD34; F5H6C8; M1P2Z0
• Molecular Weight: 15,012 Da
• NCBI Official Full Name: mitochondrial antiviral-signaling protein isoform 1
• NCBI Official Synonym Full Names: mitochondrial antiviral signaling protein
• NCBI Official Symbol: MAVS
• NCBI Official Synonym Symbols: IPS1; VISA; IPS-1; CARDIF
• NCBI Protein Information: mitochondrial antiviral-signaling protein; IFN-B promoter stimulator 1; CARD adaptor inducing IFN-beta; virus-induced signaling adaptor; virus-induced-signaling adapter; CARD adapter inducing interferon beta; putative NF-kappa-B-activating protein 031N; interferon beta promoter stimulator protein 1
• UniProt Protein Name: Mitochondrial antiviral-signaling protein
• UniProt Gene Name: MAVS
• UniProt Synonym Gene Names: IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA
• UniProt Entry Name: MAVS_HUMAN