WB (Western Blot)
(WDR45L Antibody (N-term) (AAA283691) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the WDR45L antibody detected the WDR45L protein (arrow).)
Rabbit WDR45L Polyclonal Antibody | anti-WDR45B antibody
WDR45L Antibody (N-term)
Gene Names
WDR45B; WIPI3; WDR45L; WIPI-3
Reactivity
Human (Predicted Reactivity: Mouse, Xenopus)
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
WDR45L, Antibody; WDR45L Antibody (N-term); WD repeat domain phosphoinositide-interacting protein 3; WIPI-3; WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein; WDR45B; WDR45L; WIPI3; anti-WDR45B antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Xenopus)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This WDR45L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human WDR45L.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
24-52
Sequence Length
344
Applicable Applications for anti-WDR45B antibody
ELISA, WB (Western Blot)
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed: ). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed: ). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed: ).
Cellular Location
Preautophagosomal structure. Lysosome
Tissue Location
Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(WDR45L Antibody (N-term) (AAA283691) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the WDR45L antibody detected the WDR45L protein (arrow).)
WB (Western Blot)
(WDR45L Antibody (N-term) (AAA283691) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the WDR45L antibody detected the WDR45L protein (arrow).)
Related Product Information for anti-WDR45B antibody
This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene.
Product Categories/Family for anti-WDR45B antibody
References
Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004) Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004) Venter, J.C., et al. Science 291(5507):1304-1351(2001)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38122
NCBI Official Full Name
WD repeat domain phosphoinositide-interacting protein 3
NCBI Official Synonym Full Names
WD repeat domain 45B
NCBI Official Symbol
WDR45B
NCBI Official Synonym Symbols
WIPI3; WDR45L; WIPI-3
NCBI Protein Information
WD repeat domain phosphoinositide-interacting protein 3
UniProt Protein Name
WD repeat domain phosphoinositide-interacting protein 3
UniProt Gene Name
WDR45B
UniProt Synonym Gene Names
WDR45L; WIPI3; WIPI-3; WDR45-like protein
UniProt Entry Name
WIPI3_HUMAN
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Product Notes
The WDR45B wdr45b (Catalog #AAA283691) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-52. The WDR45L Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's WDR45L can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the WDR45B wdr45b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WDR45L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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