Rabbit anti-Human X-ray repair cross-complementing protein 6 Polyclonal Antibody | anti-XRCC6 antibody

X-ray repair cross-complementing protein 6 Polyclonal Antibody

Cat. Num. AAA308846

• Gene Names: XRCC6; ML8; KU70; TLAA; CTC75; CTCBF; G22P1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: X-ray repair cross-complementing protein 6, Antibody; X-ray repair cross-complementing protein 6 Polyclonal Antibody; 5'-deoxyribose-5-phosphate lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; anti-XRCC6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total X-ray repair cross-complementing protein 6 polyclonal antibody.
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 609

• Applicable Applications for anti-XRCC6 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Recombinant Human X-ray repair cross-complementing protein 6 ptotein
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human spleen tissue using at dilution of 1:100.)

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded human kidney tissue using at dilution of 1:100.)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded mouse liver tissue using at dilution of 1:100.)

WB (Western Blot)

(All lanes: X-ray repair cross-complementing protein 6 antibody at 2ug/ml)

Related Product Information for anti-XRCC6 antibody

Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

Product Categories/Family for anti-XRCC6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 573014815
• NCBI GeneID: 2547
• NCBI Accession #: NP_001275905.1
• NCBI GenBank Nucleotide #: NM_001288976.1
• UniProt Accession #: P12956; Q6FG89; Q9UCQ2; Q9UCQ3; B1AHC8
• Molecular Weight: 65,149 Da
• NCBI Official Full Name: X-ray repair cross-complementing protein 6 isoform 1
• NCBI Official Synonym Full Names: X-ray repair complementing defective repair in Chinese hamster cells 6
• NCBI Official Symbol: XRCC6
• NCBI Official Synonym Symbols: ML8; KU70; TLAA; CTC75; CTCBF; G22P1
• NCBI Protein Information: X-ray repair cross-complementing protein 6
• UniProt Protein Name: X-ray repair cross-complementing protein 6
• UniProt Gene Name: XRCC6
• UniProt Synonym Gene Names: G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA
• UniProt Entry Name: XRCC6_HUMAN