Rabbit anti-Human, Mouse ZIP1 Polyclonal Antibody | anti-SLC39A1 antibody

ZIP1 Antibody

Cat. Num. AAA39295

• Gene Names: SLC39A1; ZIP1; ZIRTL
• Reactivity: Human, Mouse
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: ZIP1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: ZIP1, Antibody; ZIP1 Antibody; ZIP1 Antibody: ZIP1, ZIRTL, IRT1, ZIP1, CGI-08, CGI-71, Zinc transporter ZIP1, Solute carrier family 39 member 1, ZIP-1; anti-SLC39A1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of ZIP1 are known to exist; this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.
• Purity/Purification: ZIP1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid; ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)

• Applicable Applications for anti-SLC39A1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Homology: Predicted species reactivity based on immunogen sequence: Bovine: (88%)
• Immunogen: ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1.; The immunogen is located within amino acids 40 - 90 of ZIP1.
• Positive Control: 1) Cat. No. MBS151592 - Mouse Kidney Tissue Lysate; 2) Cat. No. MBS154338 - Human Kidney Tissue Slide
• Preparation and Storage: ZIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of ZIP1 in human kidney tissue with ZIP1 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of ZIP1 in human kidney tissue with ZIP1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of ZIP1 in mouse kidney tissue lysate with ZIP1 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-SLC39A1 antibody

ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

NCBI and Uniprot Product Information

• NCBI GI #: 21361423
• NCBI GeneID: 27173
• NCBI Accession #: NP_055252
• NCBI GenBank Nucleotide #: NM_014437.4
• UniProt Accession #: Q9NY26; Q5T4K1; Q8N2H7; Q9BTV0; Q9UBI7; Q9Y2Z7; Q9Y380; B4DDY7
• Molecular Weight: Predicted: 13, 36 kDa; Observed: 38 kDa
• NCBI Official Full Name: zinc transporter ZIP1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 1
• NCBI Official Symbol: SLC39A1
• NCBI Official Synonym Symbols: ZIP1; ZIRTL
• NCBI Protein Information: zinc transporter ZIP1; zrt- and Irt-like protein 1; solute carrier family 39 (zinc transporter), member 3
• UniProt Protein Name: Zinc transporter ZIP1
• UniProt Gene Name: SLC39A1
• UniProt Synonym Gene Names: IRT1; ZIP1; ZIRTL; ZIP-1; hZIP1
• UniProt Entry Name: S39A1_HUMAN