SDS-PAGE
IA2/PTPRN recombinant protein
Recombinant Human IA2/PTPRN Protein (Met687-Gln979, N-6His)
Gene Names
PTPRN; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
IA2/PTPRN; N/A; Recombinant Human IA2/PTPRN Protein (Met687-Gln979, N-6His); Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512; IA2/PTPRN recombinant protein
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Concentration
1.44 mg/mL (varies by lot)
Sequence Positions
Met687-Gln979
Sequence Length
950
Species
Human
Endotoxin
<1.0 EU per ug as determined by the LAL test.
Fusion Tag
N-6His
Preparation and Storage
Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen tempeture with blue ice/gel packs. Upon receipt , store it immediately at <-20°C.
Shipping: This product is provided as liquid. It is shipped at frozen tempeture with blue ice/gel packs. Upon receipt , store it immediately at <-20°C.
SDS-PAGE
SDS-PAGE
Related Product Information for IA2/PTPRN recombinant protein
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 35.6 kDa
Actual Protein Molecular Mass: 33 kDa
Actual Protein Molecular Mass: 33 kDa
NCBI Official Full Name
receptor-type tyrosine-protein phosphatase-like N isoform 2
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type N
NCBI Official Symbol
PTPRN
NCBI Official Synonym Symbols
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
NCBI Protein Information
receptor-type tyrosine-protein phosphatase-like N
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase-like N
UniProt Gene Name
PTPRN
UniProt Synonym Gene Names
ICA3; ICA512; ICA 5121 PublicationManual assertion based on opinion iniRef.7; ICA512-NTF; ICA512-TMF; ICA512-CCF
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Product Notes
The IA2/PTPRN ptprn (Catalog #AAA22118) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met687-Gln979. It is sometimes possible for the material contained within the vial of "IA2/PTPRN, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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