Application Data
Rabbit Estrogen Receptor beta Antibody | anti-Estrogen Receptor beta antibody
Estrogen Receptor beta
Gene Names
ESR2; Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
Reactivity
Human, Mouse, Rat
Applications
Western Blot, ELISA
Purity
The Rabbit IgG is purified by Epitope Affinity Purification.
Synonyms
Estrogen Receptor beta; N/A; Rabbit anti-ER beta; anti-Estrogen Receptor beta antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes ~53 kDa of human estrogen receptor beta. It also reacts to mouse and rat. The other species are not tested.
Purity/Purification
The Rabbit IgG is purified by Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (varies by lot)
Applicable Applications for anti-Estrogen Receptor beta antibody
WB (Western Blot), ELISA
Antigen Preparation
A synthetic peptide corresponding to the c-terminus of human Estrogen Receptor Beta.
Positive Control
MCF-7
Cellular Location
Nuclear
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Application Data
Application Data
Related Product Information for anti-Estrogen Receptor beta antibody
ER (estrogen receptor) belongs to a member of the steroid receptor superfamily. It contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). The transcriptional effects of 17b-estradiol (E2) in the body are mediated by two distinct ERs, ER-alpha and ER-beta. ER-alpha plays an important role in differentiation by regulating target genes such as that for the progesterone receptor (PR). Both the stroma and epithelium express PR, and estrogen induces PR in the stromal and glandular epithelial cells. ER-alpha and ER-beta may have opposite effects on gene transcription. ER-beta can act as a transdominant repressor on ER-alpha transcriptional activity. ER-beta acts as a modulator of ER-alpha-mediated gene transcription in the uterus, and furthermore, that it is responsible for down regulation of PR in the luminal epithelium.
References
Zhang W et al, Estrogen receptor (ER) beta, a modulator of ER alpha in the uterus. PNAS, 97 (11): 5936-5941. 2000
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53 kDa
NCBI Official Full Name
Estrogen receptor beta
NCBI Official Synonym Full Names
estrogen receptor 2 (ER beta)
NCBI Official Symbol
ESR2
NCBI Official Synonym Symbols
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
NCBI Protein Information
estrogen receptor beta; OTTHUMP00000180647; estrogen receptor beta 4; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; nuclear receptor subfamily 3 group A member 2
UniProt Protein Name
5p152
UniProt Gene Name
ESR2
UniProt Synonym Gene Names
NR3A2
UniProt Entry Name
Q7LCB3_HUMAN
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Product Notes
The Estrogen Receptor beta esr2 (Catalog #AAA71383) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Estrogen Receptor beta reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Estrogen Receptor beta can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the Estrogen Receptor beta esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Estrogen Receptor beta, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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