Application Data
Rabbit JAK2 (Paired Y1007/1008) Antibody | anti-JAK2 (Paired Y1007/1008) antibody
Rabbit anti JAK2 (Non-phospho) (Paired1007/1008)
Gene Names
JAK2; JTK10
Reactivity
Human, Rat, Mouse
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Synonyms
JAK2 (Paired Y1007/1008); N/A; Rabbit anti JAK2 (Non-phospho) (Paired1007/1008); Rabbit anti-JAK2 (Non-phospho) (Paired 1007/1008; Janus Kinase 2; anti-JAK2 (Paired Y1007/1008) antibody
Host
Rabbit
Reactivity
Human, Rat, Mouse
Specificity
This antibody recognizes JAK2 without phosphorylated sites of Tyr1007/1008. It does not cross-react with phosphospecific peptide.
Purity/Purification
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (varies by lot)
Applicable Applications for anti-JAK2 (Paired Y1007/1008) antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Antigen Preparation
A synthetic peptide surrounding to the epitope -EYYK- without any phosphorylation of JAK2 protein from human, mouse and rat origins
Positive Control
Mouse Muscle
Cellular Location
Cytoplasmic
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Application Data
Application Data
Related Product Information for anti-JAK2 (Paired Y1007/1008) antibody
The Janus tyrosine kinase family is consists of four members, JAK1, JAK2, JAK3 and Tyk2. Upon the cytokine ligand binding to its the receptors, the dimerization of the receptors occurs followed by phosphorylation of the receptors. The phosphorylation of receptors recruites the tyrosine kinase physically associated to the dimerized receptors, and the phosphorylate the kinase, thus activates the signal transducer and activator of thranscription (STAT1, 3, 5) and the other signal proteins.
References
Yogev,O., et al. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J. Biol. Chem. 278 (52), 52021-52031 (2003)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
120 kDa
NCBI Official Full Name
tyrosine-protein kinase JAK2
NCBI Official Synonym Full Names
Janus kinase 2
NCBI Official Symbol
JAK2
NCBI Official Synonym Symbols
JTK10
NCBI Protein Information
tyrosine-protein kinase JAK2; JAK-2; OTTHUMP00000021024; Janus kinase 2 (a protein tyrosine kinase)
UniProt Protein Name
Tyrosine-protein kinase JAK2
UniProt Gene Name
JAK2
UniProt Entry Name
JAK2_HUMAN
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Product Notes
The JAK2 (Paired Y1007/1008) jak2 (Catalog #AAA71388) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti JAK2 (Non-phospho) (Paired1007/1008) reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's JAK2 (Paired Y1007/1008) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the JAK2 (Paired Y1007/1008) jak2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JAK2 (Paired Y1007/1008), Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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