Syndecan-1/CD138 Recombinant Protein | CD138 recombinant protein

Syndecan-1/CD138 Protein, Human, Recombinant (ECD, hFc Tag), HPLC-verified

Cat. Num. AAA259185

• Gene Names: SDC1; SDC; CD138; SYND1; syndecan
• Purity: >= 95% as determined by SDS-PAGE.; = 95% as determined by SEC-HPLC.
• Synonyms: Syndecan-1/CD138; N/A; Syndecan-1/CD138 Protein, Human, Recombinant (ECD, hFc Tag), HPLC-verified; syndecan 1; CD138 Protein, Human; SDC Protein, Human; SYND1 Protein, Human; syndecan Protein, Human; Syndecan-1 Protein, Human; CD138 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >= 95% as determined by SDS-PAGE.; = 95% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile PBS, pH 7.4.; Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

• Species: Human
• Predicted N Terminal: Gln 18
• Endotoxin: <1.0 EU per ug protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the Human SDC1 (NP_002988.3)(Met1-Glu251) was expressed with the Fc region of human IgG1 at the C-terminus.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Application Data

Application Data

Related Product Information for CD138 recombinant protein

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

References

Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.

NCBI and Uniprot Product Information

• NCBI GI #: 29568086
• NCBI GeneID: 6382
• NCBI Accession #: NP_002988.3
• NCBI GenBank Nucleotide #: NM_002997.4
• UniProt Accession #: P18827; Q53QV0; Q546D3; Q96HB7; D6W523; AAB21434; AAB23935
• Molecular Weight: 32,462 Da
• NCBI Official Full Name: syndecan-1
• NCBI Official Synonym Full Names: syndecan 1
• NCBI Official Symbol: SDC1
• NCBI Official Synonym Symbols: SDC; CD138; SYND1; syndecan
• NCBI Protein Information: syndecan-1; CD138 antigen; syndecan proteoglycan 1; heparan sulfate proteoglycan fibroblast growth factor receptor
• UniProt Protein Name: Syndecan-1
• UniProt Gene Name: SDC1
• UniProt Synonym Gene Names: SDC; SYND1
• UniProt Entry Name: SDC1_HUMAN