SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SENP1 recombinant protein
SENP1, Active
Applications
Western Blot
Synonyms
SENP1; N/A; SENP1, Active; SuPr-2; SENP1 recombinant protein
Host
E Coli
Form/Format
Recombinant protein stored in 50mM sodium phosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Applicable Applications for SENP1 recombinant protein
WB (Western Blot), Activity Assay
Tag
HIS
Species
Human
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Related Product Information for SENP1 recombinant protein
Recombinant human SENP1 (409-end) was expressed in E Coli cells using an N-terminal His tag. The SENP1 gene accession number is NM_001267594.
SENP1 (SUMO-specific protease 1) is a protease from the de-SUMOylation protease superfamily and catalyzes the maturation of SUMO protein (small ubiquitin-related modifier). It plays a role in the regulation of androgen receptor-dependent transcription and hypoxia signaling (1). Overexpression of SENP1 was found in precancerous prostate intraepithelial neoplasia lesions and prostate cancer tissue samples, indicating the enzyme may promote prostate cancer metastasis and progression (2).
SENP1 (SUMO-specific protease 1) is a protease from the de-SUMOylation protease superfamily and catalyzes the maturation of SUMO protein (small ubiquitin-related modifier). It plays a role in the regulation of androgen receptor-dependent transcription and hypoxia signaling (1). Overexpression of SENP1 was found in precancerous prostate intraepithelial neoplasia lesions and prostate cancer tissue samples, indicating the enzyme may promote prostate cancer metastasis and progression (2).
Product Categories/Family for SENP1 recombinant protein
References
1. Wenrong, X. et al: Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-kappaB/Akt pathways. Elsevier BV 595(2): 175-179, 2016
2. Wang, Q. et al: SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene 32(19):2493-8, 2013.
2. Wang, Q. et al: SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene 32(19):2493-8, 2013.
NCBI and Uniprot Product Information
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Product Notes
The SENP1 (Catalog #AAA73975) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SENP1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), Activity Assay. Researchers should empirically determine the suitability of the SENP1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SENP1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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