Septin-7 Recombinant Protein | SEPT7 recombinant protein

Recombinant Human Septin-7

Cat. Num. AAA116773

• Gene Names: SEPT7; CDC3; CDC10; SEPT7A; NBLA02942
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Septin-7; N/A; Recombinant Human Septin-7; CDC10 protein homolog; SEPT7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-437aa; Full Length
• Sequence: SVSARSAAAEERSVNSSTMVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKIF
• Sequence Length: 437

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for SEPT7 recombinant protein

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movents.

Product Categories/Family for SEPT7 recombinant protein

Cell Biology

References

Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae.Nakatsuru S., Sudo K., Nakamura Y.Biochem. Biophys. Res. Commun. 202:82-87(1994) Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.Nagata K., Asano T., Nozawa Y., Inagaki M.J. Biol. Chem. 279:55895-55904(2004) Expression profiling the human septin gene family.Hall P.A., Jung K., Hillan K.J., Russell S.E.H.J. Pathol. 206:269-278(2005) Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.Kremer B.E., Haystead T., Macara I.G.Mol. Biol. Cell 16:4648-4659(2005) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.Nat. Biotechnol. 23:94-101(2005) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.Cell 127:635-648(2006) Structural analysis of septin 2, 6, and 7 complexes.Low C., Macara I.G.J. Biol. Chem. 281:30697-30706(2006) Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.Kremer B.E., Adang L.A., Macara I.G.Cell 130:837-850(2007) Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization.Zhu M., Wang F., Yan F., Yao P.Y., Du J., Gao X., Wang X., Wu Q., Ward T., Li J., Kioko S., Hu R., Xie W., Ding X., Yao X.J. Biol. Chem. 283:18916-18925(2008) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Septins regulate bacterial entry into host cells.Mostowy S., Nam Tham T., Danckaert A., Guadagnini S., Boisson-Dupuis S., Pizarro-Cerda J., Cossart P.PLoS ONE 4:E4196-E4196(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structural insight into filament formation by mammalian septins.Sirajuddin M., Farkasovsky M., Hauer F., Kuehlmann D., Macara I.G., Weyand M., Stark H., Wittinghofer A.Nature 449:311-315(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 148352331
• NCBI GeneID: 989
• NCBI Accession #: NP_001779.3
• NCBI GenBank Nucleotide #: NM_001788.5
• UniProt Accession #: Q16181; Q52M76; Q6NX50
• Molecular Weight: 52.5 kDa
• NCBI Official Full Name: septin-7 isoform 1
• NCBI Official Synonym Full Names: septin 7
• NCBI Official Symbol: SEPT7
• NCBI Official Synonym Symbols: CDC3; CDC10; SEPT7A; NBLA02942
• NCBI Protein Information: septin-7
• UniProt Protein Name: Septin-7
• UniProt Gene Name: SEPT7
• UniProt Synonym Gene Names: CDC10
• UniProt Entry Name: SEPT7_HUMAN