Suppressor of cytokine signaling 1 Recombinant Protein | SOCS1 recombinant protein

Recombinant Human Suppressor of cytokine signaling 1

Cat. Num. AAA18689

• Gene Names: SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Suppressor of cytokine signaling 1; Recombinant Human Suppressor of cytokine signaling 1; JAK-binding protein; JABSTAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3; SOCS1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-211aa; Full Length
• Sequence: MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for SOCS1 recombinant protein

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Product Categories/Family for SOCS1 recombinant protein

Immunology

References

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family SSI-2 and SSI-3.Minamoto S., Ikegame K., Ueno K., Narazaki M., Naka T., Yamamoto H., Matsumoto T., Saito H., Hosoe S., Kishimoto T.Biochem. Biophys. Res. Commun. 237:79-83(1997) SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.Ohya K., Kajigaya S., Yamashita Y., Miyazato A., Hatake K., Miura Y., Ikeda U., Shimada K., Ozawa K., Mano H.J. Biol. Chem. 272:27178-27182(1997) A family of cytokine-inducible inhibitors of signaling.Starr R., Willson T.A., Viney E.M., Murray L.J.L., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., Hilton D.J.Nature 387:917-921(1997) Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.Yandava C.N., Pillari A., Drazen J.M.Genomics 61:108-111(1999) Schlueter G.A new protein containing an SH2 domain that inhibits JAK kinases.Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., Miyazaki T., Leonor N., Taniguchi T., Fujita T., Kanakura Y., Komiya S., Yoshimura A.Nature 387:921-924(1997) Interaction of human suppressor of cytokine signaling (SOCS) -2 with the insulin-like growth factor-I receptor.Dey B.R., Spence S.L., Nissley P., Furlanetto R.W.J. Biol. Chem. 273:24095-24101(1998) The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.Kamizono S., Hanada T., Yasukawa H., Minoguchi S., Kato R., Minoguchi M., Hattori K., Hatakeyama S., Yada M., Morita S., Kitamura T., Kato H., Nakayama K.I., Yoshimura A.J. Biol. Chem. 276:12530-12538(2001) Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.Frantsve J., Schwaller J., Sternberg D.W., Kutok J., Gilliland D.G.Mol. Cell. Biol. 21:3547-3557(2001) SOCS proteins negative regulators of cytokine signaling.Krebs D.L., Hilton D.J.Stem Cells 19:378-387(2001) Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.Biochem. Biophys. Res. Commun. 299:793-800(2002) Cytokine signaling in the brain putting a SOCS in it?Wang J., Campbell I.L.J. Neurosci. Res. 67:423-427(2002) Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.Ben-Zvi T., Yayon A., Gertler A., Monsonego-Ornan E.J. Cell Sci. 119:380-387(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 4507233
• NCBI GeneID: 8651
• NCBI Accession #: NP_003736.1
• NCBI GenBank Nucleotide #: NM_003745.1
• UniProt Accession #: O15524; O15097; Q9NSA7
• Molecular Weight: 25.6 kDa
• NCBI Official Full Name: suppressor of cytokine signaling 1
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 1
• NCBI Official Symbol: SOCS1
• NCBI Official Synonym Symbols: JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1
• NCBI Protein Information: suppressor of cytokine signaling 1
• UniProt Protein Name: Suppressor of cytokine signaling 1
• UniProt Gene Name: SOCS1
• UniProt Synonym Gene Names: SSI1; TIP3; SOCS-1; JAB; SSI-1; TIP-3
• UniProt Entry Name: SOCS1_HUMAN