STAT6 recombinant protein

STAT6 recombinant protein

Cat. Num. AAA72895

• Gene Names: STAT6; STAT6B; STAT6C; D12S1644; IL-4-STAT
• Applications: Western Blot
• Purity: >90%
• Synonyms: STAT6; N/A; STAT6 recombinant protein; STAT6B; STAT6C; D12S1644; IL-4-STAT

• Host: Sf9 insect cells
• Purity/Purification: >90%
• Form/Format: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Concentration: 0.2 ug/ul (varies by lot)
• Sequence Length: 3838

• Applicable Applications for STAT6 recombinant protein: WB (Western Blot), Kinase Assay
• Species: Human
• Tag Information: GST tag
• Source Note: Full-length recombinant human STAT6 was expressed in Sf9 insect cells.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store product at –70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

SDS-PAGE

(The purity of STAT6 protein was determined to be >90% by densitometry.Approx. MW 138 kDa.)

Related Product Information for STAT6 recombinant protein

Full-length recombinant human STAT6 was expressed in Sf9 insect cells using an N-terminal GST tag.

Scientific Background: The STAT6 protein is a member of the STAT family of transcription factors that are activated by cytokines and phosphorylated by the receptor associated kinases. STATs form homo- or hetero-dimers that translocate to the cell nucleus where they act as transcription activators (1). STAT6 plays a central role in exerting IL4 mediated biological responses. STAT6 induces the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. STAT6 mRNA has been detected in various tissues including peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response (2).

Product Categories/Family for STAT6 recombinant protein

Transcription Proteins; Signaling Proteins - Transcription Proteins

References

1. Weidinger, S. et al: Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J. Med. Genet. 41: 658-663, 2004.
2.Wang, W. et al: The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J. Immun. 172: 97-103, 2004.

NCBI and Uniprot Product Information

• NCBI GI #: 49904291
• NCBI GeneID: 6778
• UniProt Accession #: P42226; Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9
• Molecular Weight: ~138 kDa
• NCBI Official Full Name: Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced, mRNA
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 6, interleukin-4 induced
• NCBI Official Symbol: STAT6
• NCBI Official Synonym Symbols: STAT6B; STAT6C; D12S1644; IL-4-STAT
• NCBI Protein Information: signal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT
• UniProt Protein Name: Signal transducer and activator of transcription 6
• UniProt Gene Name: STAT6
• UniProt Entry Name: STAT6_HUMAN