Application Data
NDR recombinant protein
NDR, Active
Gene Names
STK38; NDR; NDR1
Purity
>90%
Synonyms
NDR; N/A; NDR, Active; NDR recombinant protein
Host
Sf9 insect cells using baculovirus
Purity/Purification
>90%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.1 ug/ul (varies by lot)
Sequence Length
3647
Species
Human
Specific Activity
3.3 nmol/min/mg
Tag
N-Terminal GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
Application Data
Application Data
Application Data
Application Data
Related Product Information for NDR recombinant protein
Description: Full-length recombinant human NDR1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_007271.
Scientific Background: NDR or Nuclear Dbf2-related protein is a serine-threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins (1). Fas and TNF? receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase and key member of the RASSF1A/MST1 signaling cascade (2). NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells and is incorporated into the HIV-1 particles and cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
Scientific Background: NDR or Nuclear Dbf2-related protein is a serine-threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins (1). Fas and TNF? receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase and key member of the RASSF1A/MST1 signaling cascade (2). NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells and is incorporated into the HIV-1 particles and cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.
Product Categories/Family for NDR recombinant protein
References
1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995. 2. Vichalkovski A. et al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18 (23):1889-95.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
Homo sapiens serine/threonine kinase 38 (STK38), transcript variant 1, mRNA
NCBI Official Synonym Full Names
serine/threonine kinase 38
NCBI Official Symbol
STK38
NCBI Official Synonym Symbols
NDR; NDR1
NCBI Protein Information
serine/threonine-protein kinase 38
UniProt Protein Name
Serine/threonine-protein kinase 38
UniProt Gene Name
STK38
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Product Notes
The NDR stk38 (Catalog #AAA73145) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NDR, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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