Chemical Structure
(Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol.)
Doxorubicin Small Molecule
Doxorubicin Hydrochloride
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Doxorubicin; N/A; Doxorubicin Hydrochloride; Autophagy inducer; Adriamycin; Doxorubicin small molecule
Host
Synthetic
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Red solid
Solubility
Soluble in water (50 mM).
CAS Number
25316-40-9
Molecular Formula
C27H29NO11-HCl
SMILES
[C@H]2(OC1OC(C(O)C(N)C1)C)C[C@@](O)(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)C(=O)CO.[H+].[Cl-]
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol.)
Chemical Structure
(Chemical structure of Doxorubicin Hydrochloride (SIH-390), a Autophagy inducer. CAS #: 25316-40-9. Molecular Formula: C27H29NO11 . HCl. Molecular Weight: 580 g/mol.)
Related Product Information for Doxorubicin small molecule
Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
Product Categories/Family for Doxorubicin small molecule
References
1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55. 2. Chen, N. T. et al. (2012). PLoS One. 7(9). 3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66. 4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9. 5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4. 6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
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Product Notes
The Doxorubicin (Catalog #AAA103882) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Doxorubicin, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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