SDS-PAGE
TGFB1 (LAP) / TGF-beta 1 recombinant protein
Human TGFB1 (LAP) / TGF-beta 1 Protein (His Tag)
Gene Names
TGFB1; CED; LAP; DPD1; TGFB; TGFbeta
Purity
> 95 % as determined by SDS-PAGE.
Synonyms
TGFB1 (LAP) / TGF-beta 1; N/A; Human TGFB1 (LAP) / TGF-beta 1 Protein (His Tag); TGFB1; TGFB1 (LAP) / TGF-beta 1 recombinant protein
Host
HEK293 Cells
Purity/Purification
> 95 % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Positions
Met1-Arg278
Sequence Length
390
Species
Human
Tag
C-His
Endotoxin
< 1.0 EU per ug protein as determined by the LAL method.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70°C.Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
SDS-PAGE
SDS-PAGE
Related Product Information for TGFB1 (LAP) / TGF-beta 1 recombinant protein
Background: TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-gamma, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell type s, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell type s. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
Description: A DNA sequence encoding the Latency-associated peptide (LAP)of human TGFB1 (Met1-Arg278) was expressed with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the Latency-associated peptide (LAP)of human TGFB1 (Met1-Arg278) was expressed with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
29.9 KDa
NCBI Official Full Name
transforming growth factor beta-1 preproprotein
NCBI Official Synonym Full Names
transforming growth factor beta 1
NCBI Official Symbol
TGFB1
NCBI Official Synonym Symbols
CED; LAP; DPD1; TGFB; TGFbeta
NCBI Protein Information
transforming growth factor beta-1
UniProt Protein Name
Transforming growth factor beta-1
UniProt Gene Name
TGFB1
UniProt Synonym Gene Names
TGFB; TGF-beta-1; LAP
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Product Notes
The TGFB1 (LAP) / TGF-beta 1 tgfb1 (Catalog #AAA173511) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met1-Arg278. It is sometimes possible for the material contained within the vial of "TGFB1 (LAP) / TGF-beta 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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