Application Data
NR1A2/THRB recombinant protein
NR1A2/THRB Protein, Human, Recombinant (His Tag), HPLC-verified
Gene Names
THRB; GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
Purity
>= 95% as determined by SDS-PAGE.= 90% as determined by SEC-HPLC.
Synonyms
NR1A2/THRB; N/A; NR1A2/THRB Protein, Human, Recombinant (His Tag), HPLC-verified; thyroid hormone receptor, beta; C-ERBA-2 Protein, Human; C-ERBA-BETA Protein, Human; ERBA2 Protein, Human; GRTH Protein, Human; NR1A2 Protein, Human; PRTH Protein, Human; THR1 Protein, Human; THRB1 Protein, Human; THRB2 Protein, Human; NR1A2/THRB recombinant protein
Host
E coli
Purity/Purification
>= 95% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
= 90% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile 50mM Tris, 1mm Tcep, pH 8.0.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Human
Predicted N Terminal
Met
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Human THRB (P10828-1)(Glu202-Asp461) was expressed, with a polyhistidine tag at the N-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for NR1A2/THRB recombinant protein
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1/eIF4G pathway.
References
1.T. Parry, D. Ledee, M.S. Willis, M.A. Portman, Chapter 10-Nuclear Receptors and the Adaptive Response of the Heart, Editor(s): Jonathan C. Schisler, Charles H. Lang, Monte S. Willis, Endocrinology of the Heart in Health and Disease, Academic Press, 2017, 2.Lai HP, Chen MH. Atrial Fibrillation with Heart Failure in a Case with Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone Receptor beta Gene Mutation. Int J Mol Sci. 2022. 3.Ke S, et al. Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production. JCI Insight. 2021. 4.Krystian Jazdzewski, et al. Thyroid Hormone Receptor beta (THRB) Is a Major Target Gene for MicroRNAs Deregulated in Papillary Thyroid Carcinoma (PTC), The Journal of Clinical Endocrinology & Metabolism, 2011. 5.Ren B, et al. Thyroid Hormone Receptor beta Knockdown Reduces Suppression of Progestins by Activating the mTOR Pathway in Endometrial Cancer Cells. International Journal of Molecular Sciences. 2022.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52,788 Da
NCBI Official Full Name
thyroid hormone receptor beta
NCBI Official Synonym Full Names
thyroid hormone receptor, beta
NCBI Official Symbol
THRB
NCBI Official Synonym Symbols
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
NCBI Protein Information
thyroid hormone receptor beta; oncogene ERBA2; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
UniProt Protein Name
Thyroid hormone receptor beta
UniProt Gene Name
THRB
UniProt Synonym Gene Names
ERBA2; NR1A2; THR1
UniProt Entry Name
THB_HUMAN
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Product Notes
The NR1A2/THRB thrb (Catalog #AAA259197) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NR1A2/THRB, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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