SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
TPM3-PDGFR beta Recombinant Protein | TPM3-PDGFRbeta recombinant protein
TPM3-PDGFR beta, Active
Applications
Kinase Assay
Synonyms
TPM3-PDGFR beta; N/A; TPM3-PDGFR beta, Active; TPM3: CAPM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3 PDGFRB: JTK12; PDGFR; CD140B; PDGFR1; PDGF-R-beta; TPM3-PDGFRbeta recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for TPM3-PDGFRbeta recombinant protein
Kinase Assay
Tag
GST
Species
Human
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Related Product Information for TPM3-PDGFRbeta recombinant protein
Recombinant human TPM3-PDGFRB, the fusion protein [TPM3 (1-258)-PDGFRB (528-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The TPM3 gene accession number is NM_152263 and, PDGFRB's one is NM_002609.
TPM3 is an actin-binding protein that mediates myosin-actin response to calcium ions in skeletal muscles. PDGFRB is a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. PDGFRB is located at chromosome 5q31-33, and has been reported to have at least 18 fusion partners. It was uncovered that the TPM3 gene at 1q21 as a PDGFRB partner in chronic eosinophilic leukemia (CEL).
TPM3 is an actin-binding protein that mediates myosin-actin response to calcium ions in skeletal muscles. PDGFRB is a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. PDGFRB is located at chromosome 5q31-33, and has been reported to have at least 18 fusion partners. It was uncovered that the TPM3 gene at 1q21 as a PDGFRB partner in chronic eosinophilic leukemia (CEL).
Product Categories/Family for TPM3-PDGFRbeta recombinant protein
References
1. Rosati R, et al. TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia. Leukemia. 20(9):1623-4, 2006.
2. Li Z, Yang R, Zhao J, Yuan R, Lu Q, Li Q, Tse W. Molecular diagnosis andtargeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion. Pediatr Blood Cancer. 56(3):463-6. 2011.
2. Li Z, Yang R, Zhao J, Yuan R, Lu Q, Li Q, Tse W. Molecular diagnosis andtargeted therapy of a pediatric chronic eosinophilic leukemia patient carrying TPM3-PDGFRB fusion. Pediatr Blood Cancer. 56(3):463-6. 2011.
NCBI and Uniprot Product Information
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Product Notes
The TPM3-PDGFRbeta (Catalog #AAA73801) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TPM3-PDGFR beta can be used in a range of immunoassay formats including, but not limited to, Kinase Assay. Researchers should empirically determine the suitability of the TPM3-PDGFRbeta for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPM3-PDGFR beta, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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