Application Data
(The specific activity of TPM3-TRKA was determined to be 13 nmol /min/mg as per activity assay protocol.)
TPM3-TRKA recombinant protein
TPM3-TRKA Mutant, Active
Gene Names
TPM3; TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5
Purity
>70%
Synonyms
TPM3-TRKA; N/A; TPM3-TRKA Mutant, Active; TPM3-TRKA recombinant protein
Purity/Purification
>70%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.05ug/ul (varies by lot)
Specific Activity
13 nmol/min/mg
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Ships on dry ice. Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application Data
(The specific activity of TPM3-TRKA was determined to be 13 nmol /min/mg as per activity assay protocol.)
Application Data
(The specific activity of TPM3-TRKA was determined to be 13 nmol /min/mg as per activity assay protocol.)
Application Data
(The purity of TPM3-TRKA was determined to be >70% by densitometry, approx. MW 105kDa.)
Application Data
(The purity of TPM3-TRKA was determined to be >70% by densitometry, approx. MW 105kDa.)
Related Product Information for TPM3-TRKA recombinant protein
Description: Recombinant human fusion protein TPM3 (1-258)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). The oncogenic rearrangement of 5TPM3-3NTRK1 fusion gene has been found in papillary thyroid carcinomas (2).
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). The oncogenic rearrangement of 5!TPM3-3!NTRK1 fusion gene has been found in papillary thyroid carcinomas (2).
Scientific Background: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). The oncogenic rearrangement of 5TPM3-3NTRK1 fusion gene has been found in papillary thyroid carcinomas (2).
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). The oncogenic rearrangement of 5!TPM3-3!NTRK1 fusion gene has been found in papillary thyroid carcinomas (2).
Product Categories/Family for TPM3-TRKA recombinant protein
References
1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994. 2. Marta G. B. et.al: A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas. Genomics, Volume 28, Issue 1, 1 July 1995, Pages 15 -24
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~105 kDa
NCBI Official Full Name
Homo sapiens tropomyosin 3 (TPM3), transcript variant Tpm3.12, mRNA
NCBI Official Synonym Full Names
tropomyosin 3
NCBI Official Symbol
TPM3
NCBI Official Synonym Symbols
TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5
NCBI Protein Information
tropomyosin alpha-3 chain
UniProt Protein Name
Tropomyosin alpha-3 chain
UniProt Gene Name
TPM3
UniProt Synonym Gene Names
hTM5
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Product Notes
The TPM3-TRKA tpm3 (Catalog #AAA73035) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TPM3-TRKA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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