SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
USP16 recombinant protein
USP16, Active
Applications
Western Blot
Synonyms
USP16; N/A; USP16, Active; UBP-M; USP16 recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Applicable Applications for USP16 recombinant protein
WB (Western Blot), Activity Assay
Tag
GST
Species
Human
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Related Product Information for USP16 recombinant protein
Recombinant human USP16 (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The USP16 gene accession number is NM_006447.
USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells (1). USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues (2).
USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells (1). USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues (2).
Product Categories/Family for USP16 recombinant protein
References
1. Qian, Y. et al: USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports 6, 33039, 2016.
2. Adorno, M. et al: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature vol. 501(7467): 380-4, 2013.
2. Adorno, M. et al: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature vol. 501(7467): 380-4, 2013.
NCBI and Uniprot Product Information
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Product Notes
The USP16 (Catalog #AAA74103) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's USP16 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), Activity Assay. Researchers should empirically determine the suitability of the USP16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP16, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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