Vascular Endothelial Growth Factor C Active Protein | VEGFC active protein

Recombinant Human Vascular Endothelial Growth Factor C

Cat. Num. AAA38552

• Gene Names: VEGFC; VRP; Flt4-L; LMPH1D
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Vascular Endothelial Growth Factor C; N/A; Recombinant Human Vascular Endothelial Growth Factor C; VEGF C Human; Vascular Endothelial Growth Factor C Human Recombinant; VEGF-C; Vascular endothelial growth factor C; VRP; Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VEGFC; VEGFC active protein

• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: Each mg of VEGF-C Human contains 50mg BSA and 1xPBS as buffer.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 419

• Source: Sf9 Insect Cells
• Biological Activity: Measured by its ability to induce to the VEGFR-3/ FLT-4 receptor phosphorylation inPAEC/VEGFR3 cells and VEGFC induced proliferation of primary HDLEC cells.
• Solubility: It is recommended to reconstitute the lyophilized VEGF-C in sterile 18M Omega -cm H₂O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized VEGF-C although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution VEGF-C should be stored at 4°C between 2-7 days and for future use below -18°C.; ; Please prevent freeze-thaw cycles.

Related Product Information for VEGFC active protein

Description: VEGF-C Human Recombinant contains 121 amino acids residues including 6 amino acid His-tag fused at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.


Introduction: VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. Human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This proteinis a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascularendothelial cells, it is much less potent than VEGF-A.

Product Categories/Family for VEGFC active protein

Cytokines and Growth Factors; Growth Factors; VEGF

NCBI and Uniprot Product Information

• NCBI GI #: 4885653
• NCBI GeneID: 7424
• NCBI Accession #: NP_005420.1
• NCBI GenBank Nucleotide #: NM_005429.4
• UniProt Accession #: P49767; B2R9Q8
• NCBI Official Full Name: vascular endothelial growth factor C preproprotein
• NCBI Official Synonym Full Names: vascular endothelial growth factor C
• NCBI Official Symbol: VEGFC
• NCBI Official Synonym Symbols: VRP; Flt4-L; LMPH1D
• NCBI Protein Information: vascular endothelial growth factor C; FLT4 ligand DHM; vascular endothelial growth factor-related protein
• UniProt Protein Name: Vascular endothelial growth factor C
• UniProt Gene Name: VEGFC
• UniProt Synonym Gene Names: VEGF-C; Flt4-L; VRP
• UniProt Entry Name: VEGFC_HUMAN