Neuregulin 1 beta Active Protein | NRG1 active protein
Human Neuregulin 1 beta Recombinant
Purity
>95%, as determined by SDS-PAGE
Synonyms
Neuregulin 1 beta; N/A; Human Neuregulin 1 beta Recombinant; neuregulin; nrg1; nrg-1; heregulin; hrg; NRG1 active protein
Host
Human
Purity/Purification
>95%, as determined by SDS-PAGE
Form/Format
Recombinant Human NRG1 is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Sequence Length
607
Host Note
(Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Source
Optimized DNA sequence encoding Human NRG1 mature chain >sp|Q02297|2-246 was expressed in CHO cells
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Preparation and Storage
Store at Room Temperature for 3 weeks or lyophilized at -20 degree C for 12 months.
After reconsitution , Store at at 2-8 degree C for 3 weeks or at -20 degree C for 12 months.
(*)For long term storage we recommend the addition of a carrier protein at 0.1%. (*)Avoid repeated freeze/thaw cycles.
After reconsitution , Store at at 2-8 degree C for 3 weeks or at -20 degree C for 12 months.
(*)For long term storage we recommend the addition of a carrier protein at 0.1%. (*)Avoid repeated freeze/thaw cycles.
Activity
(The ED(50) was determined by the dose-dependent proliferation of human MCF-7 cells was found to be )
Product Categories/Family for NRG1 active protein
References
• the tyrosine phosphatase shp2 (ptpn11) directs Neuregulin-1/erbb signaling throughout schwann cell development .PNAS, Sep 2009; 10.1073/pnas.0904336106.
• Neuregulin-1β is associated with disease severity and adverse outcomes in chronic heart failure .Circulation, Jul 2009; 120: 310 - 317.
• the relationship among neuregulin 1–stimulated phosphorylation of akt, psychosis proneness, and habituation of arousal in nonclinical individuals .Schizophr Bull, Jun 2009; 10.1093/schbul/sbp063.
• sensory axon-derived Neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance .J. Neurosci., Jun 2009; 29: 7667 - 7678.
• downregulation of neuregulin 1 in retinal ganglion cells in experimental glaucoma .Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 2075.
• Neuregulin-1β is associated with disease severity and adverse outcomes in chronic heart failure .Circulation, Jul 2009; 120: 310 - 317.
• the relationship among neuregulin 1–stimulated phosphorylation of akt, psychosis proneness, and habituation of arousal in nonclinical individuals .Schizophr Bull, Jun 2009; 10.1093/schbul/sbp063.
• sensory axon-derived Neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance .J. Neurosci., Jun 2009; 29: 7667 - 7678.
• downregulation of neuregulin 1 in retinal ganglion cells in experimental glaucoma .Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 2075.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Weight Note: Recombinant Human NRG1 contains 245 amino acids and migrates due to glycosylation as an approximately 50 kDa protein under reducing conditions in SDS-PAGE
NCBI Official Full Name
pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c
UniProt Protein Name
Pro-neuregulin-1, membrane-bound isoform
UniProt Gene Name
NRG1
UniProt Synonym Gene Names
GGF; HGL; HRGA; NDF; SMDF; Pro-NRG1; ARIA; HRG
UniProt Entry Name
NRG1_HUMAN
