SDS-PAGE
Influenza B virus Nucleoprotein (NP) Recombinant Protein | NP recombinant protein
Recombinant Influenza B virus Nucleoprotein (NP)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Influenza B virus Nucleoprotein (NP); Recombinant Influenza B virus Nucleoprotein (NP); Nucleocapsid protein; Protein N; NP recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-560aa; Full Length
Sequence
MSNMDIDSINTGTIDKTPEELTPGTSGATRPIIKPATLAPPSNKRTRNPSPERTTTSSETDIGRKIQKKQTPTEIKKSVYKMVVKLGEFYNQMMVKAGLNDDMERNLIQNAQAVERILLAATDDKKTEYQKKRNARDVKEGKEEIDHNKTGGTFYKMVRDDKTIYFSPIKITFLKEEVKTMYKTTMGSDGFSGLNHIMIGHSQMNDVCFQRSKGLKRVGLDPSLISTFAGSTLPRRSGTTGVAIKGGGTLVDEAIRFIGRAMADRGLLRDIKAKTAYEKILLNLKNKCSAPQQKALVDQVIGSRNPGIADIEDLTLLARSMVVVRPSVASKVVLPISIYAKIPQLGFNTEEYSMVGYEAMALYNMATPVSILRMGDDAKDKSQLFFMSCFGAAYEDLRVLSALTGTEFKPRSALKCKGFHVPAKEQVEGMGAALMSIKLQFWAPMTRSGGNEVSGEGGSGQISCSPVFAVERPIALSKQAVRRMLSMNVEGRDADVKGNLLKMMNDSMAKKTSGNAFIGKKMFQISDKNKVNPIEIPIKQTIPNFFFGRDTAEDYDDLDY
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for NP recombinant protein
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP ses to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
References
Influenza B virus genome
complete nucleotide sequence of the influenza B/lee/40 virus genome RNA segment 5 encoding the nucleoprotein and comparison with the B/Singapore/222/79 nucleoprotein.Briedis D.J., Tobin M.Virology 133:448-455(1984)
Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells.Zhirnov O.P., Konakova T.E., Garten W., Klenk H.J. Virol. 73:10158-10163(1999)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
63.8 kDa
NCBI Official Full Name
nucleoprotein
NCBI Official Symbol
NP
NCBI Protein Information
nucleoprotein
UniProt Protein Name
Nucleoprotein
UniProt Gene Name
NP
UniProt Synonym Gene Names
Protein N
UniProt Entry Name
NCAP_INBLE
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Product Notes
The NP np (Catalog #AAA18565) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-560aa; Full Length. The amino acid sequence is listed below: MSNMDIDSIN TGTIDKTPEE LTPGTSGATR PIIKPATLAP PSNKRTRNPS PERTTTSSET DIGRKIQKKQ TPTEIKKSVY KMVVKLGEFY NQMMVKAGLN DDMERNLIQN AQAVERILLA ATDDKKTEYQ KKRNARDVKE GKEEIDHNKT GGTFYKMVRD DKTIYFSPIK ITFLKEEVKT MYKTTMGSDG FSGLNHIMIG HSQMNDVCFQ RSKGLKRVGL DPSLISTFAG STLPRRSGTT GVAIKGGGTL VDEAIRFIGR AMADRGLLRD IKAKTAYEKI LLNLKNKCSA PQQKALVDQV IGSRNPGIAD IEDLTLLARS MVVVRPSVAS KVVLPISIYA KIPQLGFNTE EYSMVGYEAM ALYNMATPVS ILRMGDDAKD KSQLFFMSCF GAAYEDLRVL SALTGTEFKP RSALKCKGFH VPAKEQVEGM GAALMSIKLQ FWAPMTRSGG NEVSGEGGSG QISCSPVFAV ERPIALSKQA VRRMLSMNVE GRDADVKGNL LKMMNDSMAK KTSGNAFIGK KMFQISDKNK VNPIEIPIKQ TIPNFFFGRD TAEDYDDLDY . It is sometimes possible for the material contained within the vial of "Influenza B virus Nucleoprotein (NP), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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