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IHC (Immunohistochemistry)
(CAV1/Caveolin 1 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Mouse, Rat CAV1/Caveolin 1 Polyclonal Antibody | anti-CAV1 antibody
CAV1/Caveolin 1 Rabbit anti-Rat Polyclonal (aa2-105) Antibody
Gene Names
CAV1; CGL3; BSCL3; VIP21; MSTP085
Reactivity
Mouse, Rat
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Purity
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Synonyms
CAV1/Caveolin 1; Polyclonal Antibody; CAV1/Caveolin 1 Rabbit anti-Rat Polyclonal (aa2-105) Antibody; PathPlus CAV1/Caveolin 1 Antibody (aa2-105); CAV1; Caveolin-1; CGL3; CAV; MSTP085; VIP21; BSCL3; anti-CAV1 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against CAV1.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Form/Format
0.01 M PBS, pH7.4, 0.05% ProClin 300, 50% Glycerol
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-CAV1 antibody
Immunocytochemistry (ICC), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
Target
Rat CAV1/Caveolin 1
Immunogen
Recombinant CAV1 (Ser2-Thr105) expressed in E Coli.
Conjugation
Unconjugated
Epitope
aa2-105
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
IHC (Immunohistochemistry)
(CAV1/Caveolin 1 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CAV1/Caveolin 1 Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(CAV1/Caveolin 1 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistchemistry)
(CAV1/Caveolin 1 Antibody-Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CAV1/Caveolin 1 Antibody-Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemistry)
(CAV1/Caveolin 1 Antibody-Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Recombinant protein.)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Recombinant protein.)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western blot of recombinant CAV1/Caveolin 1. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western blot of recombinant CAV1/Caveolin 1. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Mouse Heart lysate; ;Primary Ab: 3ug/ml Rabbit Anti-Rat CAV1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Mouse Heart lysate; ;Primary Ab: 3ug/ml Rabbit Anti-Rat CAV1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Rat Heart lysate; ;Primary Ab: 3ug/ml Rabbit Anti-Rat CAV1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
WB (Western Blot)
(CAV1/Caveolin 1 Antibody-Western Blot; Sample: Rat Heart lysate; ;Primary Ab: 3ug/ml Rabbit Anti-Rat CAV1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
Related Product Information for anti-CAV1 antibody
Caveolin 1 antibody is an unconjugated rabbit polyclonal antibody to mouse Caveolin 1 (CAV1)(aa2-105). Validated for ICC, IHC and WB.
CAV1 is a scaffolding protein encoded that is a primary component of caveolae plasma membranes in most cell types. CAV1 plays an important role in cell metabolism and is involved in autophagy, fatty acid metabolism, glutaminolysis, glycolysis and mitochondrial bioenergetics. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. In cancer, CAV1 can be a driver of tumorigenesis and also a suppressor in different contexts. For example, it appears to have an oncogenic role and may be an effective target of therapy in triple negative breast cancer with aberrant TP53 expression. Conversely, higher expression of CAV1 in some liver cancer patients is associated with improved survival, and loss of CAV1 alongside APC knockout has been shown to increase colorectal tumorigenesis. In immunohistochemistry of normal tissue, it has membranous positivity in endothelial cells, adipocytes, as well as pneumocytes and basal cells of squamous epithelia in various tissues throughout the body.
CAV1 is a scaffolding protein encoded that is a primary component of caveolae plasma membranes in most cell types. CAV1 plays an important role in cell metabolism and is involved in autophagy, fatty acid metabolism, glutaminolysis, glycolysis and mitochondrial bioenergetics. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. In cancer, CAV1 can be a driver of tumorigenesis and also a suppressor in different contexts. For example, it appears to have an oncogenic role and may be an effective target of therapy in triple negative breast cancer with aberrant TP53 expression. Conversely, higher expression of CAV1 in some liver cancer patients is associated with improved survival, and loss of CAV1 alongside APC knockout has been shown to increase colorectal tumorigenesis. In immunohistochemistry of normal tissue, it has membranous positivity in endothelial cells, adipocytes, as well as pneumocytes and basal cells of squamous epithelia in various tissues throughout the body.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Onco Targets Ther. 2019; 12: 1539 -1552, PMID: 30881011; Mol Cancer 15, 71 (2016), DOI:10.1186/s12943-016-0558-7; Journal of Clinical Oncology 2015 33:28_suppl, 134-134, DOI: 10.1200/jco.2015.33.28_suppl.134;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,472 Da
NCBI Official Full Name
caveolin-1 isoform alpha
NCBI Official Synonym Full Names
caveolin 1, caveolae protein, 22kDa
NCBI Official Symbol
CAV1
NCBI Official Synonym Symbols
CGL3; BSCL3; VIP21; MSTP085
NCBI Protein Information
caveolin-1; cell growth-inhibiting protein 32
UniProt Protein Name
Caveolin-1
UniProt Gene Name
CAV1
UniProt Synonym Gene Names
CAV
UniProt Entry Name
CAV1_HUMAN
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Product Notes
The CAV1 cav1 (Catalog #AAA21374) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAV1/Caveolin 1 Rabbit anti-Rat Polyclonal (aa2-105) Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CAV1/Caveolin 1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB). Researchers should empirically determine the suitability of the CAV1 cav1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAV1/Caveolin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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