Chemical Structure
ex229 activator
ex229 (compound 991)
Purity
>98%
Synonyms
ex229; N/A; ex229 (compound 991); ex-229; ex 229; ex229 activator
Purity/Purification
>98%
Solubility
DMSO
Formula
C24H18ClN3O3
SMILES
CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC5=C(C=C4)N(C=C5)C)Cl)C(=O)O
CAS Number
1219739-36-2
Targets
Target: AMPK alpha1ß1ß1-Value: 0.06 µM (Kd)
Target: AMPK alpha1ß2y1-Value: 0.51 µM (Kd)
Target: AMPK alpha2ß1y1
Value: 0.06 µM (Kd)
Target: AMPK alpha1ß2y1-Value: 0.51 µM (Kd)
Target: AMPK alpha2ß1y1
Value: 0.06 µM (Kd)
Solubility
In vitro
DMSO: 11 mg/mL (25.47 mM)
Water: Insoluble
Ethanol: Insoluble
DMSO: 11 mg/mL (25.47 mM)
Water: Insoluble
Ethanol: Insoluble
Stock Solutions
0.1 mM: Concentration 1mg: 23.16 mL/ Solvent Volume 5mg: 115.78 mL/ Mass 10mg: 231.55 mL
0.5 mM: Concentration 1mg: 4.63 mL/ Solvent Volume 5mg: 23.16 mL/ Mass 10mg: 46.31 mL
1 mM: Concentration 1mg: 2.32 mL/ Solvent Volume 5mg: 11.58 mL/ Mass 10mg: 23.16 mL
5 mM: Concentration 1mg: 0.46 mL/ Solvent Volume 5mg: 2.32 mL/ Mass 10mg: 4.63 mL
0.5 mM: Concentration 1mg: 4.63 mL/ Solvent Volume 5mg: 23.16 mL/ Mass 10mg: 46.31 mL
1 mM: Concentration 1mg: 2.32 mL/ Solvent Volume 5mg: 11.58 mL/ Mass 10mg: 23.16 mL
5 mM: Concentration 1mg: 0.46 mL/ Solvent Volume 5mg: 2.32 mL/ Mass 10mg: 4.63 mL
Preparation and Storage
Store lyophilized at -20ºC, keep desiccated.
In solution, store at -20ºC to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
In solution, store at -20ºC to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Chemical Structure
Chemical Structure
Related Product Information for ex229 activator
EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.
Product Categories/Family for ex229 activator
References
CN Koyani,.et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
Similar Products
Product Notes
The ex229 (Catalog #AAA210694) is an Activator and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ex229, Activator" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.