Application Data
(The purity of Human PDGFRB/CD140b Protein (Cat. AAA281430 ) was greater than 95% as determined by SEC-HPLC.)
PDGFRB/CD140b Active Protein | PDGFRB active protein
Recombinant Human PDGFRB/CD140b Protein
Gene Names
PDGFRB; IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1
Purity
>90% by SDS-PAGE.
Synonyms
PDGFRB/CD140b; N/A; Recombinant Human PDGFRB/CD140b Protein; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT; PDGFRB active protein
Purity/Purification
>90% by SDS-PAGE.
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Source
HEK293 Cells
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Tags
C-hFc&His
Bio-Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant Human PDGF-B at 2 ?g/mL (100 uL/well) can bind recombinant Human PDGFRB. The EC50 of Human PDGFRB is 30.48 ng/mL
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
Fc, 6xHis tag at the C-terminus
Preparation and Storage
Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week. Avoid repeated freeze/thaw cycles
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week. Avoid repeated freeze/thaw cycles
Application Data
(The purity of Human PDGFRB/CD140b Protein (Cat. AAA281430 ) was greater than 95% as determined by SEC-HPLC.)
Application Data
(The purity of Human PDGFRB/CD140b Protein (Cat. AAA281430 ) was greater than 95% as determined by SEC-HPLC.)
Application Data
(Immobilized recombinant Human PDGF-B at 2ug/mL (100 uL/well) can bind recombinant Human PDGFRB, the EC50 of Human PDGFRB is 30.48 ng/mL.)
Application Data
(Immobilized recombinant Human PDGF-B at 2ug/mL (100 uL/well) can bind recombinant Human PDGFRB, the EC50 of Human PDGFRB is 30.48 ng/mL.)
SDS-PAGE
(Recombinant Human PDGFRB/CD140b Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 110-140 kDa.)
SDS-PAGE
(Recombinant Human PDGFRB/CD140b Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 110-140 kDa.)
Related Product Information for PDGFRB active protein
Description: Recombinant Human PDGFRB/CD140b Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu33-Phe530 (Glu241Asp)) of human PDGFRB/CD140b (Accession #NP_002600.1) fused with an Fc, 6xHis tag at the C-terminus.
Background: The protein is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Background: The protein is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Product Categories/Family for PDGFRB active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
platelet-derived growth factor receptor beta isoform 1
NCBI Official Synonym Full Names
platelet derived growth factor receptor beta
NCBI Official Symbol
PDGFRB
NCBI Official Synonym Symbols
IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1
NCBI Protein Information
platelet-derived growth factor receptor beta
UniProt Protein Name
Platelet-derived growth factor receptor beta
UniProt Gene Name
PDGFRB
UniProt Synonym Gene Names
PDGFR; PDGFR1; PDGF-R-beta; PDGFR-beta; PDGFR-1
UniProt Entry Name
PGFRB_HUMAN
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Product Notes
The PDGFRB pdgfrb (Catalog #AAA281430) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PDGFRB/CD140b, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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