sFRP1 active protein
sFRP1 protein
Gene Names
SFRP1; FRP; FRP1; FrzA; FRP-1; SARP2
Purity
> or = 97% by SDS-PAGE and HPLC
Synonyms
sFRP1; N/A; sFRP1 protein; SFRP-1 protein; Secreted Frizzled Related Protein 1 protein; sFRP-1 protein; sFRP 1; sFRP 1 protein; Secreted Apoptosis Related Protein-2 protein; sFRP-1; Soluble Frizzled Related Protein-1 protein; SARP-2 protein; sFRP1 active protein
Purity/Purification
> or = 97% by SDS-PAGE and HPLC
Concentration
20ug lyophilized (varies by lot)
Sequence
SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
Sequence Length
314
Source
HeLa cells
Species
Human
Protein Type
Recombinant
Biological Significance
Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas.
Bioactivity
Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5 ug/ml.
Endotoxin Levels
< 0.1 ng/ug (1 EU/ug).
Contaminants
Endotoxin: <0.1ng/ug(<1EU/ug)
Form
Lyophilized powder. Centrifuge the vial prior to opening. Reconstitute with water to a concentration of 0.1-1mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containg a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Biohazard
Use appropriate laboratory precautions when handling this product.
Preparation and Storage
Ships ambient or refrigerated; after receipt, store at 4 degree C short term, -20 degree C long term
Related Product Information for sFRP1 active protein
Purified recombinant Human sFRP1 protein
Product Categories/Family for sFRP1 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Secreted frizzled-related protein 1
NCBI Official Synonym Full Names
secreted frizzled-related protein 1
NCBI Official Symbol
SFRP1
NCBI Official Synonym Symbols
FRP; FRP1; FrzA; FRP-1; SARP2
NCBI Protein Information
secreted frizzled-related protein 1
UniProt Protein Name
Secreted frizzled-related protein 1
UniProt Gene Name
SFRP1
UniProt Synonym Gene Names
FRP; FRP1; SARP2; FRP-1; sFRP-1; SARP-2
UniProt Entry Name
SFRP1_HUMAN
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Product Notes
The sFRP1 sfrp1 (Catalog #AAA75573) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK. It is sometimes possible for the material contained within the vial of "sFRP1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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