SDS-PAGE
(NativeSDS-PAGEofEGCG-stabilizedalphasynucleinoligomers(AAA254094))
Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized) Recombinant Protein | SNCA recombinant protein
Human Recombinant Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized)
Gene Names
SNCA; PD1; NACP; PARK1; PARK4
Applications
SDS-Page, Western Blot
Purity
>95%; Ion-exchange Purified
Synonyms
Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized); N/A; Human Recombinant Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized); Alpha Synuclein Oligomers; Alpha synuclein protein; Alpha-synuclein oligomer; Alpha synuclein protein oligomer; Alpha-synuclein protein; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein; NACP protein; SNCA protein; PARK1 protein; Alpha synuclein oligomers; Alpha Synuclein Protein Oligomers; SYN protein; Parkinson's disease familial 1 Protein; SNCA recombinant protein
Host
E coli
Purity/Purification
>95%; Ion-exchange Purified
Form/Format
PBS pH 7.4
Concentration
Lot/batch specific. See included datasheet. (varies by lot)
Sequence Length
Full length
Applicable Applications for SNCA recombinant protein
Invitro Assay, SDS-PAGE, WB (Western Blot)
Species
Human
Conjugation
No Tag
Research Area
Neuroscience, Neurodegeneration, Alzheimer's Disease, Tangles & Tau, Neuroscience, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience, Neurodegeneration, Multiple System Atrophy
Cellular Localization
Cytoplasm, Membrane, Nucleus
Certificate of Analysis
Certified >95% pure using SDS-PAGE analysis. Low endotoxin <5 EU/mL @ 2mg/mL.
Preparation and Storage
Store at -80 degree C
SDS-PAGE
(NativeSDS-PAGEofEGCG-stabilizedalphasynucleinoligomers(AAA254094))
SDS-PAGE
(NativeSDS-PAGEofEGCG-stabilizedalphasynucleinoligomers(AAA254094))
SDS-PAGE
(SDS-PAGEofEGCG-stabilizedalphasynucleinoligomers(AAA254094))
SDS-PAGE
(SDS-PAGEofEGCG-stabilizedalphasynucleinoligomers(AAA254094))
Application Data
(TEMofEpigallocatechingallate(EGCG)-stabilizedalphasynucleinoligomers(AAA254094).Magnification:1kx)
Application Data
(TEMofEpigallocatechingallate(EGCG)-stabilizedalphasynucleinoligomers(AAA254094).Magnification:1kx)
Related Product Information for SNCA recombinant protein
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Epigallocatechin Gallate (EGCG) reduces alpha synuclein fibril formation in favour of spherical soluble oligomers (7).
Product Categories/Family for SNCA recombinant protein
References
1. "Genetics Home Reference: SNCA". US National Library of Medicine. (2013).2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.7. Ehrnhoefer, D. E. et al. (2008). Nat Struct Mol Biol. 15(6):558-566.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,460 Da
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein, alpha (non A4 component of amyloid precursor)
NCBI Official Symbol
SNCA
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
NCBI Protein Information
alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
Similar Products
Product Notes
The SNCA (Catalog #AAA254094) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized) can be used in a range of immunoassay formats including, but not limited to, Invitro Assay, SDS-PAGE, WB (Western Blot). Researchers should empirically determine the suitability of the SNCA for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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