Application Data
ALPPL2/ALPG recombinant protein
Recombinant Mouse ALPPL2/ALPG Protein (His Tag), HPLC-verified
Gene Names
Alppl2; EAP; Akp5; C77216; D1Ertd816e
Purity
>= 95% as determined by SDS-PAGE.= 90% as determined by SEC-HPLC.
Synonyms
ALPPL2/ALPG; N/A; Recombinant Mouse ALPPL2/ALPG Protein (His Tag), HPLC-verified; ALPPL2/ALPG recombinant protein
Host
HEK293 Cells
Purity/Purification
>= 95% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
= 90% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, 5% Trehalose, 10% Glycerol, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Mouse
Predicted N Terminal
Val 19
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Mouse ALPG (P24823)(Met1-Ser502) was expressed with a polyhistidine tag at the C-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for ALPPL2/ALPG recombinant protein
Alkaline phosphatase, placental-like 2 (ALPPL2 or ALPG) is a (GPI)-anchored membrane protein and a member of the human alkaline phosphatase family. Not expressed in normal tissue except for the trophoblast, ALPPL2 exhibits a rare tumor specificity with immunohistochemistry (IHC) on tumor tissue arrays revealing its expression in 43% of mesotheliomas, 60% of ovarian cancers, 36% of pancreatic cancers, 18% of gastric cancers, and 100% of seminomas. Furthermore, expression of ALPPL2 was significantly increased in gastric adenocarcinoma (P?
References
1. Yang Su, et al. ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Cancer Res, 2020. doi: 10.1158/0008-5472.CAN-20-1418 2. Axel, et al. Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits. bioRxiv, 2021. doi: 10.1101/2021.01.06.425642 3. Shuang Liu, et al. High expression of ALPPL2 is associated with poor prognosis in gastric cancer, Human Pathology, 2019. doi: 10.1016/j.humpath.2018.11.019 4. Pooja Dua, et al. Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein. Cancer Res 2013. doi: 10.1158/0008-5472.CAN-12-3682 5. Bi, Yan, et al. Identification of ALPPL2 as a naive pluripotent state-specific surface protein essential for human naive pluripotency regulation. Cell Reports, 2020. doi: 10.1016/j.celrep.2020.02.090
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,202 Da
NCBI Official Full Name
alkaline phosphatase, placental-like
NCBI Official Synonym Full Names
alkaline phosphatase, placental-like 2
NCBI Official Symbol
Alppl2
NCBI Official Synonym Symbols
EAP; Akp5; C77216; D1Ertd816e
NCBI Protein Information
alkaline phosphatase, placental-like
UniProt Protein Name
Alkaline phosphatase, placental-like
UniProt Gene Name
Alppl2
UniProt Synonym Gene Names
Akp5; Eap; EAP
UniProt Entry Name
PPBN_MOUSE
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Product Notes
The ALPPL2/ALPG alppl2 (Catalog #AAA259273) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ALPPL2/ALPG, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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