IL-17A active protein
Recombinant mouse IL-17A protein
Gene Names
Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A
Applications
SDS-Page
Purity
> 95% by SDS-PAGE
Synonyms
IL-17A; N/A; Recombinant mouse IL-17A protein; Interleukin-17A; IL17A; IL-17; Il17; Cytotoxic T-lymphocyte-associated antigen 8. Ctla-8; Ctla8; IL-17A active protein
Host
Baculovirus
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Concentration
0.5mg/ml (determined by absorbance at 280nm) (varies by lot)
Sequence Positions
26-158aa
Sequence
Ala 26
AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
Applicable Applications for IL-17A active protein
Bioactivity, SDS-PAGE
Species
Mouse
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Tag
His-Tag
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Related Product Information for IL-17A active protein
IL-17A, also known as CTLA?8, is a cytokine that belongs to the Interleukin?17 family. It produced by activated T cells and plays an important role in anti?microbial and chronic inflammation. Mouse IL?17A shares 61% amino acid sequence identity with human IL?17A. It promotes protective mucosal and epidermal inflammation in response to microbial infection and induces chemokine production, neutrophil influx, and the production of antibacterial peptides. It can stimulate the expression of IL-6 and PTGS2/COX-2, as well as enhance the production of nitric oxide(NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Also, IL?17A has been shown to exert either tumorigenic or anti?tumor effects. Recombinant mouse IL-17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for IL-17A active protein
References
Yao Z., et al. (1995) J. Immunol. 155:5483-5436.
Kennedy J., et al. (1996) J. Interferon Cytokine Res. 16:611-617.
Kennedy J., et al. (1996) J. Interferon Cytokine Res. 16:611-617.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,490 Da
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
Il17a
NCBI Official Synonym Symbols
Il17; Ctla8; IL-17; Ctla-8; IL-17A
NCBI Protein Information
interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8
UniProt Protein Name
Interleukin-17A
UniProt Gene Name
Il17a
UniProt Synonym Gene Names
Ctla8; Il17; IL-17; IL-17A; CTLA-8
UniProt Entry Name
IL17_MOUSE
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Product Notes
The IL-17A il17a (Catalog #AAA48986) is an Active Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-158aa. AAA Biotech's IL-17A can be used in a range of immunoassay formats including, but not limited to, Bioactivity, SDS-PAGE. Researchers should empirically determine the suitability of the IL-17A il17a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Ala 26 AAII PQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAAPrecautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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