Bioactivity
(Human IFN-alpha 2 (CAT# IFN0502) is coated at 10 ug/ml (100 ul/well) can bind Human IFN-alpha/beta R2 in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894). The ED50 range )
IFN-alpha/beta R2 Active Protein | IFN-alpha/betaR2 active protein
Recombinant Human IFN-alpha/beta R2 protein
Gene Names
IFNAR2; IFN-R; IFNABR; IFNARB; IFN-alpha-REC
Applications
SDS-Page
Purity
>90% by SDS-PAGE
Synonyms
IFN-alpha/beta R2; N/A; Recombinant Human IFN-alpha/beta R2 protein; Interferon alpha/beta receptor 2; IFNAR2; IFN-alpha binding protein; Interferon alpha binding protein; Type I interferon receptor 2; interferon alpha/beta receptor 2 isoform a; IFN-R-2; IFNABR; IFNARB; IFN-alpha-REC; IFN-R; IMD45; IFN-alpha/betaR2 active protein
Host
Baculovirus
Purity/Purification
>90% by SDS-PAGE
Form/Format
Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence Positions
27-243aa
Sequence
ISYDSPDYTD ESCTFKISLR NFRSILSWEL KNHSIVPTHY TLLYTIMSKP EDLKVVKNCA NTTRSFCDLT DEWRSTHEAY VTVLEGFSGN TTLFSCSHNF WLAIDMSFEP PEFEIVGFTN HINVMVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPEIK GNMSGNFTYI IDKLIPNTNY CVSVYLEHSD EQAVIKSPLK CTLLPPGQES ESAESAK
Applicable Applications for IFN-alpha/betaR2 active protein
Bioactivity, SDS-PAGE
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Species
Human
Tag
hIgG-His-Tag
Predicted N-term
Ile
Bioactivity
Measured by its binding ability in a functional ELISA with Human IFN-alpha 2 in the presence of Human IFN-alpha/beta R1. The ED50 range <= 500ng/ml.
Preparation and Storage
Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.
Bioactivity
(Human IFN-alpha 2 (CAT# IFN0502) is coated at 10 ug/ml (100 ul/well) can bind Human IFN-alpha/beta R2 in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894). The ED50 range )
Bioactivity
(Human IFN-alpha 2 (CAT# IFN0502) is coated at 10 ug/ml (100 ul/well) can bind Human IFN-alpha/beta R2 in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894). The ED50 range )
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
SDS-PAGE
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)
Related Product Information for IFN-alpha/betaR2 active protein
IFN-alpha/beta R2, also known as IFNAR2, is a member of the class II cytokine receptor family. This protein is the principal ligand binding subunit of the receptor. Ligand bindnig is stabilized by the subsequent association with IFNAR1 and forms the signaling compelx recptor. It also plays the role in STAT1, STAT2, and STAT3 activation. Recombinant human IFN-alpha/beta R2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for IFN-alpha/betaR2 active protein
References
Grazziola C, et al, (2005) Int J Oncol 26:129-140. Ortiz A, et al, (2019) Cancer Cell 35:33-45.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,384 Da
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform a
NCBI Official Synonym Full Names
interferon (alpha, beta and omega) receptor 2
NCBI Official Symbol
IFNAR2
NCBI Official Synonym Symbols
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
NCBI Protein Information
interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; human interferon alpha/beta receptor; interferon alpha binding protein; interferon-alpha/beta receptor beta chain; type I interferon receptor 2
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Gene Name
IFNAR2
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2
UniProt Entry Name
INAR2_HUMAN
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Product Notes
The IFN-alpha/betaR2 ifnar2 (Catalog #AAA48365) is an Active Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-243aa. AAA Biotech's IFN-alpha/beta R2 can be used in a range of immunoassay formats including, but not limited to, Bioactivity, SDS-PAGE. Researchers should empirically determine the suitability of the IFN-alpha/betaR2 ifnar2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ISYDSPDYTD ESCTFKISLR NFRSILSWEL KNHSIVPTHY TLLYTIMSKP EDLKVVKNCA NTTRSFCDLT DEWRSTHEAY VTVLEGFSGN TTLFSCSHNF WLAIDMSFEP PEFEIVGFTN HINVMVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPEIK GNMSGNFTYI IDKLIPNTNY CVSVYLEHSD EQAVIKSPLK CTLLPPGQES ESAESAKPrecautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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